A randomized, prospective, double-blind study on the efficacy of dead sea salt nasal irrigations.

Friedman M; Vidyasagar R; Joseph N

首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >A randomized, prospective, double-blind study on the efficacy of dead sea salt nasal irrigations.

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A randomized, prospective, double-blind study on the efficacy of dead sea salt nasal irrigations.

机译：一项死海盐鼻冲洗功效的随机，前瞻性，双盲研究。

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OBJECTIVE: The objective of this randomized, prospective, double-blind study was to compare nasal irrigation using hypertonic Dead Sea salt (DSS) solution with hypertonic saline in the treatment of chronic rhinosinusitis and improvement of quality of life (QOL). METHODS: With Institutional Review Board approval, 42 adults seeking treatment for chronic rhinosinusitis in a tertiary university-affiliated medical center were studied. After history and endonasal examination, computed tomography imaging, and QOL survey (Standardized Rhinoconjunctivitis Quality of Life Questionnaire [RQLQ(S)]), patients were randomized to self-administered hypertonic saline spray and irrigation twice daily or hypertonic DSS spray and irrigation. Patients were reassessed weekly and at 1 month. RESULTS: Both groups had similar symptoms and RQLQ(S) scores before treatment and had significant improvement after treatment. However, the DSS patients had significantly better symptom relief and only the DSS group showed improved RQLQ(S) scores. CONCLUSIONS: We present a short-term study providing level I evidence on the superiority of DSS over saline nasal irrigation for treatment of chronic rhinosinusitis.

机译：目的：这项随机，前瞻性，双盲研究的目的是比较使用高渗死海盐（DSS）溶液和高渗盐水进行鼻腔冲洗治疗慢性鼻鼻窦炎和改善生活质量（QOL）。方法：在机构审查委员会的批准下，研究了在大学附属医学中心对42例寻求治疗慢性鼻鼻窦炎的成年人进行的研究。经过病史和鼻内检查，计算机断层扫描显像和QOL调查（标准的鼻结膜炎生活质量问卷[RQLQ（S）]）后，患者被随机分配到每天两次自我自我管理的高渗盐水喷雾和冲洗或高渗DSS喷雾冲洗。每周和第1个月对患者进行重新评估。结果：两组患者治疗前的症状和RQLQ（S）评分均相似，而治疗后则有明显改善。但是，DSS患者的症状缓解明显更好，只有DSS组的RQLQ（S）评分有所改善。结论：我们提供了一项短期研究，提供了I级证据证明DSS优于盐水鼻腔冲洗治疗慢性鼻-鼻窦炎。

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《The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery ..》 |2006年第6期|共5页
作者
Friedman M; Vidyasagar R; Joseph N;
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正文语种 eng
中图分类口腔科学;
关键词
Nasal Lavage Fluid; Saline Solution; Hypertonic; Sinusitis; 盐水; 高渗; 鼻窦炎;

机译：Nasal Lavage Fluid;Saline Solution;Hypertonic;Sinusitis;盐水;高渗;鼻窦炎;

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机译：一项死海盐鼻冲洗功效的随机，前瞻性，双盲研究。
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A randomized, prospective, double-blind study on the efficacy of dead sea salt nasal irrigations.

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