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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Prognostic factors in well-differentiated thyroid carcinoma.
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Prognostic factors in well-differentiated thyroid carcinoma.

机译：高分化甲状腺癌的预后因素。

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摘要

OBJECTIVES: To test the prognostic significance of standard clinicopathologic factors in patients with well-differentiated thyroid carcinoma (WDTC). STUDY DESIGN: A retrospective chart review of the thyroid cancer database at Mount Sinai Hospital (Toronto, Canada 1963-2000) was carried out. METHODS: All patients consecutively treated for WDTC with a follow-up period of at least 5 years were eligible for inclusion. Relevant patient, tumor, treatment, and outcome data were collected. The main outcome measures were recurrence rate, actuarial overall, and disease-specific survival at 20 years. RESULTS: Three hundred and thirty-three patients (F 275, M 58) with a median age of 39.7 (range 9-82.9) years were eligible for inclusion in this study (median follow-up 10.4 years, range 5-34.4 years, minimum 5 years). The recurrence rate was 15.6% (52 /333). The overall and disease-specific survival at 10 years was 97.5% and 98.5%, respectively. Likewise, the overall and disease-specific survival at 20 years was 88.4% and 93.3%, respectively. Clinicopathologic factors significant on multivariate regression for the development of disease recurrence included family history of WDTC, advanced stage, and total thyroidectomy (all P < .05). Similarly, advanced stage on presentation was associated with a worse disease-specific survival on multivariate regression (all P < .05). There was a trend for age 60 or greater to predict disease-specific survival (P = .09). CONCLUSIONS: WDTC is associated with a significant recurrence rate but good disease-specific survival. The most important prognostic factors are family history of WDTC, extent of surgical treatment (i.e., total thyroidectomy), and advanced initial stage of disease, with a trend for age 60 years and older.
机译：目的：检验标准临床病理因素对高分化甲状腺癌（WDTC）患者的预后意义。研究设计：对西奈山医院（加拿大多伦多1963-2000年）的甲状腺癌数据库进行了回顾性图表审查。方法：所有连续接受WDTC治疗且随访期至少为5年的患者均符合纳入条件。收集相关的患者，肿瘤，治疗和结果数据。主要结果指标是复发率，总体精算值和20年特定疾病生存率。结果：333名患者（F 275，M 58）的中位年龄为39.7岁（范围9-82.9）岁，有资格被纳入本研究（中位随访期10.4年，范围5-34.4岁，至少5年）。复发率为15.6％（52/333）。 10年总生存率和疾病特异性生存率分别为97.5％和98.5％。同样，20年的总生存率和疾病特异性生存率分别为88.4％和93.3％。对于疾病发展的多因素回归显着影响的临床病理因素包括WDTC家族史，晚期和全甲状腺切除术（所有P <.05）。同样，呈报的晚期与多因素回归的疾病特异性生存率差相关（所有P <.05）。 60岁或更高年龄有预测疾病特异性存活的趋势（P = .09）。结论：WDTC与显着的复发率相关，但具有良好的疾病特异性生存率。最重要的预后因素是WDTC的家族病史，手术治疗的程度（即全甲状腺切除术）和疾病的早期初期阶段，其趋势是60岁以上。

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