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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Different risk factors in basaloid and common squamous head and neck cancer.
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Different risk factors in basaloid and common squamous head and neck cancer.

机译：基底基底和常见鳞状头颈癌的不同危险因素。

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OBJECTIVES/HYPOTHESIS: The prevalence of human papillomavirus (HPV), herpes simplex virus (HSV), cigarette smoking and alcohol abuse was compared between two histological subgroups of head and neck cancer. STUDY DESIGN: Retrospective review. METHODS: Paraffin-embedded, histologically confirmed surgical specimens from the oropharynx, hypopharynx and larynx, comprising 67 conventional squamous cell carcinomas (SCC) and 10 basaloid squamous cell carcinomas (BSCC), were analyzed for the presence of HPV and HSV DNA using polymerase chain reaction (PCR) techniques. The PCR products were verified by direct sequencing. Patient charts were reviewed for clinical data and risk factors. RESULTS: Given an overall HPV DNA detection rate of 32.5%, a basaloid morphology of the carcinomas correlated significantly with occurrence of HPV DNA (P =.0001). An association could also be demonstrated between basaloid appearance and evidence of HSV DNA (single and combined with HPV DNA; P =.014 and 0.0429, respectively), even if this result based on a low overall HSV DNA detection rate (6.5%). Demonstration of viral DNA in the BSCC specimens was not related to tobacco or alcohol consumption. In contrast, cigarette smoking proved as significant characteristic of SCC (P =.0087). Alcohol abuse occurred also predominately in patients with SCC, but without statistical significance. CONCLUSION: These results hint at differences in the etiology of two distinct histological entities of head and neck cancer. Further research in this field could complete these preliminary data and provide the background for specific preventive strategies.
机译：目的/假设：比较了头颈癌的两个组织学亚组中人乳头瘤病毒（HPV），单纯疱疹病毒（HSV），吸烟和酗酒的患病率。研究设计：回顾性审查。方法：使用聚合酶链分析法分析了口咽，下咽和喉的石蜡包埋的，经组织学证实的手术标本，包括67个常规鳞状上皮癌（SCC）和10个基底样鳞状上皮癌（BSCC）。反应（PCR）技术。通过直接测序验证PCR产物。复查患者图表以获取临床数据和危险因素。结果：鉴于总的HPV DNA检出率为32.5％，癌的基底形态与HPV DNA的发生显着相关（P = .0001）。即使基于较低的总体HSV DNA检出率（6.5％），该结果也可能表明基底基底的出现与HSV DNA的证据之间存在关联（分别与HPV DNA结合;分别为P = .014和0.0429）。 BSCC标本中病毒DNA的证明与烟草或酒精消费无关。相反，事实证明吸烟是SCC的重要特征（P = .0087）。 SCC患者也主要发生酗酒，但无统计学意义。结论：这些结果暗示着头颈癌的两种不同的组织学在病因学上的差异。在该领域的进一步研究可以完善这些初步数据，并为具体的预防策略提供背景。

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