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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Heme oxygenase (HO)-1 is upregulated in the nasal mucosa with allergic rhinitis.
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Heme oxygenase (HO)-1 is upregulated in the nasal mucosa with allergic rhinitis.

机译：在变应性鼻炎的鼻粘膜中，血红素加氧酶（HO）-1上调。

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BACKGROUND: Heme oxygenase (HO) is considered to be an antioxidant enzyme that catabolizes heme to produce carbon monoxide (CO) and biliverdin. Three isoforms of HO have been discovered. Recently, HO-1 has been found to be upregulated after allergic inflammations of the lower airway. OBJECTIVE: The objective of this study was to address the expression of HO isoenzymes 1 and 2 in the nasal mucosa of patients with allergic rhinitis as well as normal control subjects. METHODS: Nasal mucosa from 30 patients with persistent allergic rhinitis as well as from 10 normal volunteers was used in this study. We used immunofluorescent technique, Western blotting, and real-time quantitative polymerase chain reaction to localize and quantify the expression of these isoenzymes in normal and allergic human nasal tissues. RESULTS: We found that HO-1 is expressed in the epithelial cells of seromucinous glands and macrophages with significant upregulation of its glandular expression in allergic rhinitis but with no difference in its macrophage expression between the study groups in contrast to HO-2 that is expressed in the vascular endothelial lining cells as well as macrophages with no marked difference between the study groups. CONCLUSION: We demonstrated that expression of HO-1, but not HO-2, was upregulated within the nasal tissues in allergic rhinitis inflammation, and understanding the induction of HO-1 expression may provide for better management of allergic rhinitis that involves oxidative stress.
机译：背景：血红素加氧酶（HO）被认为是一种抗氧化酶，能分解血红素以产生一氧化碳（CO）和胆绿素。已发现HO的三种同工型。近来，已发现HO-1在下呼吸道的过敏性炎症后被上调。目的：研究HO同工酶1和2在变应性鼻炎患者以及正常对照者鼻黏膜中的表达。方法：本研究使用了30例持续性变应性鼻炎患者的鼻黏膜以及10例正常志愿者的鼻黏膜。我们使用了免疫荧光技术，蛋白质印迹和实时定量聚合酶链反应来定位和量化这些同工酶在正常和过敏性人鼻组织中的表达。结果：我们发现HO-1在浆液性腺体和巨噬细胞的上皮细胞中表达，在变应性鼻炎中其腺体表达显着上调，但与HO-2的表达相比，研究组之间其巨噬细胞表达没有差异在血管内皮细胞和巨噬细胞中的表达没有差异，研究组之间没有显着差异。结论：我们证明了在过敏性鼻炎炎症的鼻组织中，HO-1的表达上调，但HO-2的表达没有上调，并且了解HO-1表达的诱导可能为涉及氧化应激的过敏性鼻炎提供更好的处理方法。

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