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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Pharyngo-UES contractile reflex in patients with posterior laryngitis.
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Pharyngo-UES contractile reflex in patients with posterior laryngitis.

机译：咽后炎患者的咽-UES收缩反射。

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BACKGROUND: Earlier studies have shown that stimulation of the human pharynx by injection of minute amounts of water stimulates the pharyngo-UES contractile reflex. It has been suggested that this reflex may be activated during pharyngeal reflux of gastric and/or esophageal content, thus increasing the UES pressure and possibly preventing further entry of the refluxate into the pharynx. However, the integrity of this reflex in patients with posterior laryngitis has not been studied. AIM: Evaluate the pharyngo-UES contractile reflex in a group of patients with objective findings of posterior laryngitis. METHODS: Fourteen consecutive patients with posterior laryngitis (mean age, 48+/-6 y) and 13 healthy volunteers (mean age, 53+/-6 y) were studied by concurrent pharyngeal water stimulation and UES manometry. RESULTS: The threshold volume required to evoke the pharyngo-UES contractile reflex in the laryngitis group (0.4+/-0.05 mL) was significantly higher than that of the control (0.2+/-0.04 mL) (P < .05). Following stimulation of the pharyngo-UES contractile reflex, the maximum postinjection pressure in patients (75+/-6 mm Hg) was similar to that of the controls (78+/-6 mm Hg). The percent increase in UES pressure following stimulation of the reflex in the laryngitis group (99%+/-15%) was significantly higher than that of controls (55%+/-11%) (P < .05). CONCLUSIONS: Compared with normal controls, a significantly larger volume of liquid is required to trigger this reflex in patients with posterior laryngitis. When triggered, the maximum UES pressure induced by the pharyngo-UES contractile reflex is similar between the two groups. These findings suggest an altered afferent sensory limb of this reflex in patients with posterior laryngitis.
机译：背景：较早的研究表明，通过注入少量水刺激人咽会刺激咽-UES的收缩反射。已经建议在胃和/或食道内容物的咽返流期间可以激活该反射，从而增加UES压力并可能防止返流进一步进入咽部。但是，尚未对后喉炎患者这种反射的完整性进行研究。目的：评估一组具有后喉炎客观发现的患者的咽-UES收缩反射。方法：通过同时进行咽水刺激和UES测压研究了连续14例后喉炎患者（平均年龄48 +/- 6岁）和13名健康志愿者（平均年龄53 +/- 6岁）。结果：喉炎组（0.4 +/- 0.05 mL）引起咽咽UES收缩反射所需的阈值量显着高于对照组（0.2 +/- 0.04 mL）（P <.05）。刺激咽-UES收缩反射后，患者的最大注射后压力（75 +/- 6 mm Hg）与对照组（78 +/- 6 mm Hg）相似。喉炎组反射引起的UES压力增加百分比（99％+ /-15％）显着高于对照组（55％+ /-11％）（P <.05）。结论：与正常对照组相比，后喉炎患者需要大量液体来触发这种反射。触发后，两组咽咽UES收缩反射所引起的最大UES压力相似。这些发现提示后喉炎患者该反射的传入感觉肢体改变。

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