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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Malignancies of the ear in irradiated patients of nasopharyngeal carcinoma.
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Malignancies of the ear in irradiated patients of nasopharyngeal carcinoma.

机译：鼻咽癌放疗患者的耳部恶性肿瘤。

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摘要

OBJECTIVES/HYPOTHESIS: To report on the clinical profiles and treatment experiences of patients with second primary ear malignancy after treatment of nasopharyngeal carcinoma (NPC). STUDY DESIGN: Retrospective case series. METHODS: A retrospective review of the clinical outcomes and pathology of 11 irradiated NPC patients who subsequently had second primary malignancies of the ear at a single institution. RESULTS: Ten tumors were squamous cell carcinoma and one tumor was chondrosarcoma occurring within the radiation field of previous treatment for NPC. The interval between previous radiotherapy and diagnosis of ear malignancy was 3 to 27 years with a median time of 17 years. Six tumors were located in the external auditory canal, two in the middle ear cavity, two in the periauricular region and one in the mastoid cavity. Four patients underwent surgery, and the other seven patients underwent surgery plus adjuvant radiotherapy. The 3-year disease-free and overall survival rates were 30.3% and 20%, respectively. CONCLUSIONS: Postirradiated malignancy of the ear is extremely rare, but is one of the causes of death for NPC long-term survivors despite curative-intended treatment with surgery plus adjuvant radiotherapy is instituted.
机译：目的/假设：报告鼻咽癌（NPC）治疗后第二原发性耳部恶性肿瘤患者的临床概况和治疗经验。研究设计：回顾性病例系列。方法：回顾性分析11例经放射治疗的NPC患者，这些患者随后在同一家医院接受了第二次原发性耳部恶性肿瘤治疗。结果：10例为鳞状细胞癌，1例为软骨肉瘤。既往放疗与诊断为耳部恶性肿瘤的间隔时间为3至27年，中位时间为17年。六个肿瘤位于外耳道中，两个位于中耳腔，两个位于耳周区域，一个位于乳突腔中。四名患者接受了手术，其他七名患者接受了手术加辅助放疗。三年无病生存率和总生存率分别为30.3％和20％。结论：耳后放疗后的恶性肿瘤极为罕见，但这是鼻咽癌长期幸存者的死亡原因之一，尽管已制定了手术治疗和辅助放疗的治疗方案。

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