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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Combined Use of Perioperative TSH-Stimulated 18F-FDG PET/CT Imaging and Gamma Probe Radioguided Surgery to Localize and Verify Resection of Iodine Scan-Negative Recurrent Thyroid Carcinoma
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Combined Use of Perioperative TSH-Stimulated 18F-FDG PET/CT Imaging and Gamma Probe Radioguided Surgery to Localize and Verify Resection of Iodine Scan-Negative Recurrent Thyroid Carcinoma

机译：围手术期TSH刺激的18F-FDG PET / CT成像和Gamma探针放射引导手术的结合使用，以定位和验证碘扫描阴性的复发性甲状腺癌的切除

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摘要

For most forms of well-differentiated thyroid carcinoma, locoregional surgery with or without adjuvant ra-dioiodide therapy remains the mainstay of treatment. Although treatment typically yields high rates of long-term survival for well-differentiated thyroid carcinoma,1 the recent use of more comprehensive surveillance methods including radioiodide scanning, stimulated thyreoglobulin testing, and high-resolution neck ultrasound supplemented with fine needle aspiration biopsy, detects persistent or recurrent disease in some patients in whom clinical exam is otherwise negative after therapy. Provided that such disease can be localized, surgery has been suggested to be the preferred initial method of treatment particularly if the disease is felt to possess low avidity for radio-iodine. Unfortunately, surgical therapy can be challenging particularly in situations where disease volume is small, nondiscrete, difficult to localize, or where proximity of functionally important structures makes intentional radical resection excessively morbid or impractical.
机译：对于大多数形式的高度分化的甲状腺癌，局部或局部联合或不联合辅助放疗均是治疗的主要手段。尽管治疗通常可为分化良好的甲状腺癌带来较高的长期生存率，[1]最近使用更全面的监测方法，包括放射性碘扫描，刺激性甲状腺球蛋白检测以及高分辨率颈部超声，并辅以细针穿刺活检，可发现持续性或某些患者在治疗后临床检查阴性的复发性疾病。如果可以定位这种疾病，则建议手术是首选的初始治疗方法，特别是如果认为该疾病对放射性碘的亲和力较低。不幸的是，特别是在疾病体积小，不离散，难以定位或功能上重要的结构接近使得故意进行根治性切除术变得过分病态或不切实际的情况下，外科手术疗法尤其具有挑战性。

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