...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Cochlear preservation after meningitis: an animal model confirmation of adjunctive steroid therapy.
【24h】

Cochlear preservation after meningitis: an animal model confirmation of adjunctive steroid therapy.

机译：脑膜炎后耳蜗的保存：辅助类固醇疗法的动物模型确认。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE/HYPOTHESIS: The objective of the present study was to determine whether treating pneumococcal meningitis with a combined antibiotic and steroid regime will prevent cochlear damage, a common pneumococcal meningitis side effect. STUDY DESIGN: This was a prospective animal study. METHODS: Gerbils were randomly assigned to three experimental groups. Animals in group 1, the control animals, received intrathecal saline injections. Animals in groups 2 and 3 received intrathecal injections of Streptococcus pneumoniae to induce meningitis. Although group 2 solely was treated for 7 days with intraperitoneal penicillin injections (48,0000 units), group 3 received, in addition to the antibiotic for 4 days, 0.5 mg/kg intraperitoneal dexamethasone injections. Three months after the meningitis was induced, the animals' cochlear function was determined using auditory brainstem responses (ABRs). Fifteen frequencies were tested, five octaves at three steps per octave between 2 and 50 kHz. RESULTS: ABR thresholds were significantly elevated only in group 2. When compared with group 1, ABR thresholds were 19 dB higher (P<.05). Frequencies at the low-frequency end of the hearing range were affected more than the midfrequencies. Animals that received dexamethasone had 2-dB higher thresholds than the control group (P>.05). CONCLUSIONS: Dexamethasone therapy in conjunction with antibiotic therapy preserves cochlear function in cases of S. pneumoniae meningitis in the Mongolian gerbil model.
机译：目的/假设：本研究的目的是确定联合抗生素和类固醇治疗肺炎球菌性脑膜炎是否可以预防耳蜗损害，这是常见的肺炎球菌性脑膜炎的副作用。研究设计：这是一项前瞻性动物研究。方法：将沙鼠随机分为三个实验组。第1组的动物，对照动物，接受鞘内注射盐水。第2组和第3组的动物接受鞘内注射肺炎链球菌诱导脑膜炎。尽管第2组仅接受腹膜内青霉素注射（48,0000单位）治疗7天，但除抗生素4天外，第3组还接受了0.5 mg / kg腹膜内地塞米松注射。诱发脑膜炎三个月后，使用听觉脑干反应（ABR）确定动物的耳蜗功能。测试了15个频率，其中5个八度音阶在2至50 kHz之间以每个八度音阶为三个步阶。结果：仅在第2组中ABR阈值显着升高。与第1组相比，ABR阈值高19 dB（P <.05）。听力范围低频端的频率比中频受到的影响更大。接受地塞米松的动物阈值比对照组高2 dB（P> .05）。结论：在蒙古沙鼠模型中，地塞米松治疗与抗生素治疗相结合可保留肺炎链球菌脑膜炎病例的耳蜗功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号