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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Use of fibrin glue to protect tissue during CO2 laser surgery.
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Use of fibrin glue to protect tissue during CO2 laser surgery.

机译：在CO2激光手术期间使用纤维蛋白胶保护组织。

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OBJECTIVE: Accidental injury of tissues during CO2 laser irradiation can lead to serious morbidity, especially during ear, nose, and throat, neurosurgical, and plastic-reconstructive procedures. This experimental study describes a new technique in which vital structures are coated with a thin layer of fibrin glue to protect them from accidental CO2 laser irradiation. STUDY DESIGN/MATERIALS AND METHODS: The femoral neurovascular bundles (femoral artery, vein, and nerve) of 12 rats were exposed. On one side the bundle was coated with fibrin glue, which is a biological two-component glue consisting of fibrinogen solution and thrombin. Upon application, an elastic mass on the neurovascular bundle was formed. The contralateral neurovascular bundle was left uncoated. Subsequently both bundles were subjected to CO2 laser irradiation at different powers (5, 7, and 9 W), with an irradiation time of 0.1 seconds. Light microscopy was performed at 30 minutes and 2 days after surgery. RESULTS: No macroscopic visible hemorrhages occurred during laser irradiation in the glue-coated bundle. Light microscopic evaluation revealed an undamaged neurovascular bundle without any signs of thermal damage. In the uncoated bundles intraoperative hemorrhages resulting from laser energy occurred in all specimens. Furthermore, severe thermal damage was present in arteries, veins, and nerves. CONCLUSIONS: Intraoperative coating with fibrin glue can serve as a shield to protect vital structures such as arteries, veins, and nerves from accidental CO2 laser exposure.
机译：目的：在CO2激光照射过程中意外伤害组织会导致严重的发病率，尤其是在耳，鼻，喉，神经外科手术和整形外科手术期间。这项实验研究描述了一种新技术，其中重要结构用纤维蛋白胶薄层覆盖，以保护它们免受意外的CO2激光照射。研究设计/材料和方法：暴露12只大鼠的股神经血管束（股动脉，静脉和神经）。束的一侧涂有纤维蛋白胶，这是一种由纤维蛋白原溶液和凝血酶组成的生物两组分胶。应用后，在神经血管束上形成了弹性块。对侧神经血管束未涂膜。随后，两个束都以不同的功率（5、7和9 W）经受CO2激光辐照，辐照时间为0.1秒。在手术后30分钟和2天进行光学显微镜检查。结果：涂胶束中的激光照射过程中未发生肉眼可见的大出血。光学显微镜评估显示未受损的神经血管束没有任何热损伤迹象。在未涂覆的束中，所有标本中都发生了由激光能量引起的术中出血。此外，在动脉，静脉和神经中存在严重的热损伤。结论：术中用纤维蛋白胶进行涂层可作为屏蔽层，以保护重要的结构，例如动脉，静脉和神经，防止意外的CO2激光照射。

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