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首页> 外文期刊>The American Journal of Cardiology >Predictors of Development of Echocardiographic Left Ventricular Diastolic Dysfunction in the Subjects Aged 40 to 59 Years (from the Oulu Project Elucidating Risk of Atherosclerosis Study)
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Predictors of Development of Echocardiographic Left Ventricular Diastolic Dysfunction in the Subjects Aged 40 to 59 Years (from the Oulu Project Elucidating Risk of Atherosclerosis Study)

机译：40至59岁受试者的超声心动图左室舒张功能障碍发展的预测指标（来自Oulu项目，阐明了动脉粥样硬化研究的风险）

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Factors in the middle age that are associated with the risk for development of diastolic dysfunction in long term are not fully established. The Oulu Project Elucidating Risk of Atherosclerosis OPERA study randomly selected middle-aged subjects with hypertension and age- and gender-matched control subjects (n = 1,045, age 51 +/- 6 years, men 49.8%). Alter >20 years of follow-up, majority of the subjects still alive were available for reexaminations (n = 600). After excluding the subjects with mitral regurgitation, left ventricular ejection fraction <50%, and those from whom echocardiographic septal E/E' could not be reliably measured, the present analysis included 460 subjects. E/E' was divided into 3 subgroups (subgroup 1: E/E' <= 8, subgroup 2: 8 < E/E' < 15, subgroup 3: E/E' >= 15), subgroup 3 suggesting a significant diastolic dysfunction. Several baseline variables were associated with diastolic dysfunction: greater age (p = 0.001), female gender (p = 0.001), shorter height (p < 0.001), larger body mass index (p = 0.008), greater systolic blood pressure (p = 0.001), greater pulse pressure (p <0.001), lower barorefiex sensitivity (p = 0.007), lower estimated glomerular filtration rate (p = 0.02), greater atrial natriuretic peptide (p = 0.001), greater fasting plasma glucose (p = 0.001), more common occurrence of diabetes (p = 0.011), and more common usage of antihypertensive medication (p = 0.001). After adjustments in the multivariate model, only systolic blood pressure (p = 0.001), shorter height (p = 0.002), and estimated glomerular filtration rate (p = 0.006) retained a significant association with the risk of developing diastolic dysfunction. In conclusion, greater systolic blood pressure, short height, and lower estimated glomerular filtration rate of the middle-aged subjects were the main determinants of development of diastolic dysfunction during a 20-year follow-up. (C) 2015 Elsevier Inc. All rights reserved.
机译：与中长期存在舒张功能障碍发展风险相关的中年因素尚未完全确定。 Oulu项目阐明了动脉粥样硬化的风险OPERA研究随机选择了患有高血压的中年受试者以及年龄和性别相匹配的对照受试者（n = 1,045，年龄51 +/- 6岁，男性49.8％）。经过20年以上的随访，大多数仍活着的受试者可以接受复检（n = 600）。在排除二尖瓣反流，左心室射血分数<50％的患者以及无法可靠测量超声心动图间隔E / E'的受试者后，本分析包括460名受试者。 E / E'分为3个子组（子组1：E / E'<= 8，子组2：8 = 15），子组3表明舒张功能障碍。几个基线变量与舒张功能障碍有关：年龄较大（p = 0.001），女性（p = 0.001），身高较短（p <0.001），体重指数较大（p = 0.008），收缩压较高（p = 0.001），较高的脉压（p <0.001），较低的Barorefiex敏感性（p = 0.007），较低的估计肾小球滤过率（p = 0.02），较大的心钠素（p = 0.001），较高的空腹血糖（p = 0.001） ），更常见的糖尿病（p = 0.011）和抗高血压药物的更常见用法（p = 0.001）。在对多元模型进行调整后，只有收缩压（p = 0.001），身高较短（p = 0.002）和估计的肾小球滤过率（p = 0.006）与发生舒张功能障碍的风险之间存在显着相关性。总之，中年受试者的收缩压升高，身高矮小和估计的肾小球滤过率降低是在20年随访中发展舒张功能障碍的主要决定因素。 （C）2015 Elsevier Inc.保留所有权利。

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