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首页> 外文期刊>The American Journal of Cardiology >Comparison of Outcomes After One-Versus-Two Transcatheter Aortic Valve Implantation During a Same Procedure (froth the FRANCE2 Registry)
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Comparison of Outcomes After One-Versus-Two Transcatheter Aortic Valve Implantation During a Same Procedure (froth the FRANCE2 Registry)

机译：同一过程中一两次主动脉瓣置入术后的结果比较（FRANCE2注册处的泡沫）

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摘要

Analysis of the causes, outcomes, and mortality of patients with severe symptomatic aortic stenosis requiring the implantation of 2 valves during transcatheter aortic valve implantation was conducted from the French Aortic National Core Valve and Edwards 2 (FRANCE2) registry. Pre- and postprocedural data from 3,919 patients from January 2010 to December 2011 (Core Valve or Edwards) were collated and analyzed. Characteristics of patients requiring immediate second valve procedures were compared with those of the other patients. The 72 patients (1.8%) who underwent implantation of a second valve were studied. Indications were device malpositioning (72%) and embolization (28%). Clinical and echocardiographic characteristics of patients receiving 2 valves were comparable with those of the other patients. The 2-year survival rate was 51.7% for patients with 2 valves as opposed to 62.3% for those with 1 valve (p <0.001). The need for a second valve was an independent predictor of all-cause (hazard ratio 2.32, 95% confidence interval 1.50 to 3.60, p <0.001) and cardiovascular (hazard ratio 2.64, 95% confidence interval 1.35 to 5.15, p <0.001) mortality at 2 years. During follow-up, clinical and echocardiographic data remained similar between the 2 groups. In conclusion, in the FRANCE2 study, the main causes for second valve implantation during the same procedure were malpositioning and embolization. Although the procedure was feasible, it was accompanied by excess mortality. Valve hemodynamic status was preserved during the course of follow-up. (C) 2015 Elsevier Inc. All rights reserved.
机译：根据法国主动脉国家核心瓣膜和Edwards 2（FRANCE2）登记表分析了严重症状性主动脉瓣狭窄的原因，结果和死亡率，这些患者需要在经导管主动脉瓣植入术中植入2个瓣膜。整理并分析了2010年1月至2011年12月（Core Valve或Edwards）的3,919例患者的术前和术后数据。将需要立即进行第二瓣膜手术的患者的特征与其他患者的特征进行了比较。研究了接受第二瓣膜植入术的72例患者（1.8％）。适应症为器械错位（72％）和栓塞（28％）。接受2个瓣膜的患者的临床和超声心动图特征与其他患者相当。 2个瓣膜患者的2年生存率为51.7％，而1个瓣膜的患者为22.3％（p <0.001）。是否需要第二个瓣膜是全因（危险比2.32，95％置信区间1.50至3.60，p <0.001）和心血管（危险比2.64，95％置信区间1.35至5.15，p <0.001）的独立预测因子2年时死亡率。在随访期间，两组之间的临床和超声心动图数据保持相似。总之，在FRANCE2研究中，同一步骤中第二瓣膜植入的主要原因是错位和栓塞。尽管该程序是可行的，但伴随着死亡率过高。在随访过程中保留了瓣膜血流动力学状态。 （C）2015 Elsevier Inc.保留所有权利。

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