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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >The therapeutic effect of OK-432 (picibanil) sclerotherapy for benign neck cysts.
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The therapeutic effect of OK-432 (picibanil) sclerotherapy for benign neck cysts.

机译：OK-432（吡哌醇）硬化疗法治疗颈部良性囊肿的疗效。

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BACKGROUND AND OBJECTIVES: In general, benign neck cysts are treated by surgical excision. This can present technical difficulties and frequent recurrences, because of insufficient surgery. Sclerosing agents such as OK-432 have been tested for the nonsurgical treatment of these cysts. We have assessed the efficacy of OK-432 sclerotherapy for benign neck cysts. MATERIALS AND METHODS: The study group consisted of 75 patients (42 men, 33 women) diagnosed with and treated for benign neck cysts between March 2001 and December 2007 by intralesional injection of OK-432. The liquid content of each cyst was aspirated as much as possible, and the same volume of OK-432 solution was injected. Patients were assessed by ultrasonography or computerized tomography, and therapeutic outcomes and adverse effects were evaluated by patient age, sex, cyst type, and number of injections. RESULTS: Of the 75 treated patients, 31 (41.3%) showed total shrinkage, seven (9.3%) showed near-total shrinkage (>90% of cyst volume), five (6.6%) showed marked shrinkage (>70% of cyst volume), and 17 (22.7%) showed partial shrinkage (<70% of cyst volume). No response was seen in 15 patients (20%). Despite repeated sclerotherapy, eight patients (10.7%) showed recurrences. Minor adverse effects of therapy included fever, localized pain, and odynophagia but these complications spontaneously disappeared within several days. CONCLUSIONS: OK-432 sclerotherapy is a safe and effective primary alternative to surgery in patients with benign neck cysts.
机译：背景与目的：一般而言，良性颈部囊肿是通过手术切除来治疗的。由于手术不足，这可能会导致技术困难和频繁复发。已经对诸如OK-432之类的硬化剂进行了非手术治疗这些囊肿的测试。我们评估了OK-432硬化疗法治疗颈部良性囊肿的疗效。材料与方法：该研究组由75例患者（42例男性，33例女性）组成，在2001年3月至2007年12月之间，通过病灶内注射OK-432诊断并治疗了良性颈部囊肿。尽可能抽吸每个囊肿的液体含量，并注入相同体积的OK-432溶液。通过超声或计算机断层扫描对患者进行评估，并根据患者的年龄，性别，囊肿类型和注射次数评估治疗效果和不良反应。结果：在75例接受治疗的患者中，有31例（41.3％）表现出总萎缩，七例（9.3％）表现出近乎完全萎缩（> 90％的囊肿体积），五例（6.6％）表现出明显的萎缩（> 70％的囊肿）体积），其中17例（22.7％）出现局部收缩（<囊肿体积的70％）。 15名患者（20％）未见反应。尽管进行了反复的硬化疗法，但仍有8例（10.7％）复发。治疗的轻微不良反应包括发烧，局部疼痛和吞咽痛，但这些并发症在几天内自发消失。结论：OK-432硬化疗法是治疗颈部良性囊肿的一种安全，有效的主要替代手术方法。

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