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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >In reference to Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy (Laryngoscope 119:359-369, 2009).
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In reference to Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy (Laryngoscope 119:359-369, 2009).

机译：参照随机，双盲，安慰剂对照试验，探讨通过圆窗导管递送持续鼓膜内地塞米松治疗系统治疗失败后重度至重度特发性特发性感音神经性听力损失的安全性和有效性（喉镜119：359-369，2009） 。

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We read the recently published article, "Randomized, Double Blind, Placebo Controlled Trial on the Safety and Efficacy of Continuous Intratympanic Dexa-methasone Delivered Via a Round Window Catheter for Severe to Profound Sudden Idiopathic Sensorineural Hearing Loss After Failure of Systemic Therapy," with great interest.1 The subjects for this study were patients whose hearing level did not recover after intravenous high-dose prednisolone (initial dose: 250 mg/d). We think that 250 mg/d of prednisolone is high compared to the dose used in many countries for the treatment of idiopathic sudden sensorineural hearing loss. We considered the possibility that the authors excluded the "high-dose steroid necessary group" from the subjects. The hearing improvement was not as good as that reported by Ho et al.,2 who performed intratympanic steroid therapy after the failure of systemic therapy (initial dose: oral methylprednisolone, 1 mg/kg/d).
机译：我们阅读了最近发表的文章，“关于通过圆窗导尿管进行持续性鼓膜内Dexa-methasone的安全性和有效性的随机，双盲，安慰剂对照试验，该药物严重导致严重的特发性特发性感觉神经性听力损失，但治疗失败。” 1本研究的受试者为静脉大剂量泼尼松龙（初始剂量：250 mg / d）后听力水平未恢复的患者。与许多国家用于治疗特发性突然感觉神经性听力损失的剂量相比，我们认为泼尼松龙的剂量为250 mg / d。我们考虑了作者将“大剂量类固醇必要组”从受试者中排除的可能性。听力改善不如Ho等[2]报道的那样，后者在全身治疗失败后进行了鼓膜内类固醇治疗（初始剂量：口服甲基泼尼松龙，1 mg / kg / d）。

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