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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >IgE response to staphylococcal enterotoxins in adenoid tissues from atopic children.
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IgE response to staphylococcal enterotoxins in adenoid tissues from atopic children.

机译：IgE对特应性儿童腺样组织中葡萄球菌肠毒素的反应。

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OBJECTIVES/HYPOTHESIS: To evaluate local production of staphylococcal superantigen (SAg)-specific IgE in adenoid tissue and to compare its prevalence with that in the tonsil and serum, as well as its relationship with markers of allergic inflammation within adenoid tissue. STUDY DESIGN: Prospective randomized study. METHODS: We recruited 18 atopic children who had rhinitis symptoms and were sensitized to more than one common aeroallergen, and 22 nonatopic children undergoing adenotonsillectomy. Immunoassays were performed using adenoid tissue homogenate to quantify the levels of three staphylococcal SAg-specific IgE (SEA, SEB, and TSST-1), total IgE, eosinophil cationic protein (ECP), mast cell tryptase, and soluble CD23. RESULTS: Three kinds of SAg-specific IgE were detected in the adenoid and tonsil tissues of atopic patients, but not in those of nonatopic patients. In atopic children, the prevalence of SEA-, SEB-, and TSST-1-specific IgE in adenoid tissues (61.1%, 27.8%, 33.3%, respectively) were higher than those in tonsil tissues (38.9%, 5.6%, 11.1%, respectively) and in sera (11.1%, 27.8%, 16.7%, respectively). Subjects with high SEA levels showed significantly higher serum and adenoid total IgE, with higher eosinophilia. Significant correlations were noted between SAg-specific IgE levels and tryptase levels in adenoid tissue. CONCLUSIONS: Local specific IgE response to staphylococcal SAgs, especially SEA may contribute to ongoing allergic inflammation in adenoid tissue from atopic children.
机译：目的/假设：评估腺样体组织中葡萄球菌超抗原（SAg）特异性IgE的局部产生，并比较其与扁桃体和血清中的流行情况，以及其与腺样体组织中过敏性炎症标志物的关系。研究设计：前瞻性随机研究。方法：我们招募了18例有鼻炎症状且对一种以上的常见气敏原敏感的过敏性儿童，以及22例接受腺扁桃体切除术的非过敏性儿童。使用腺样组织匀浆进行免疫测定，以定量三种葡萄球菌SAg特异性IgE（SEA，SEB和TSST-1），总IgE，嗜酸性粒细胞阳离子蛋白（ECP），肥大细胞类胰蛋白酶和可溶性CD23的水平。结果：在特应性患者的腺样体和扁桃体组织中检测到三种SAg特异性IgE，而在非特应性患者中未检测到。在特应性儿童中，腺样体组织中SEA-，SEB-和TSST-1特异性IgE的患病率（分别为61.1％，27.8％，33.3％）高于扁桃体组织（38.9％，5.6％，11.1）分别为％和血清中（分别为11.1％，27.8％，16.7％）。具有较高SEA水平的受试者表现出明显更高的血清和腺样总IgE，以及更高的嗜酸性粒细胞增多。腺样组织中SAg特异性IgE水平与类胰蛋白酶水平之间存在显着相关性。结论：对葡萄球菌SAgs尤其是SEA的局部特异性IgE反应可能导致特应性儿童腺样组织中持续的过敏性炎症。

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