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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response?
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Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response?

机译：喉癌放疗：13种标记物可以预测反应吗？

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OBJECTIVES/HYPOTHESIS: To find biomarkers associated with response to radiotherapy in laryngeal cancer that can be used together with clinical parameters to improve outcome prediction. METHODS: In this study, 26 patients irradiated for laryngeal carcinomas with a local recurrence within two years (cases) and 33 patients without recurrence (controls) were included. All pretreatment biopsies were arrayed onto a tissue array. Immunohistochemistry was performed for 13 biomarkers that were selected from the literature as potential predictors for radioresponse in head and neck (HN) cancer: Bcl-2, Bcl-xL, p16, p21, p27, p53, cyclin D1, HIF-1alpha, CA9, COX-2, EGFR, ki-67, and pRB. RESULTS: Univariate logistic regression models showed borderline statistically significant increased relative risks, with positivity for CA9, COX-2, and p53. Goeman's global testing revealed an overall association between outcome and the 13 markers together with clinical variables. The most important markers were CA9 and COX-2. CONCLUSIONS: In laryngeal carcinoma, hypoxia and COX-2 overexpression provide a stronger contribution to an increased risk of local recurrence after radiotherapy compared with the well-known candidate markers p53, Bcl-2, and cyclin D1. However, no robust expression profile for the prediction of radioresistance was found.
机译：目的/假设：寻找与喉癌放疗反应相关的生物标志物，可以将其与临床参数一起使用以改善预后。方法：在这项研究中，包括26例在两年内局部复发的喉癌患者（病例）和33例未复发的患者（对照组）。将所有预处理的活检样品排列在组织阵列上。对从文献中选择的13种生物标志物进行了免疫组织化学分析，这些标志物可作为头颈癌（HN）放射反应的潜在预测因子：Bcl-2，Bcl-xL，p16，p21，p27，p53，细胞周期蛋白D1，HIF-1alpha，CA9 ，COX-2，EGFR，ki-67和pRB。结果：单因素逻辑回归模型显示，边界线在统计学上显着增加相对风险，对CA9，COX-2和p53呈阳性。 Goeman的全球测试揭示了结果与13种标记物以及临床变量之间的整体关联。最重要的标记是CA9和COX-2。结论：与众所周知的候选标记物p53，Bcl-2和cyclin D1相比，在喉癌中，低氧和COX-2过表达对放疗后局部复发的风险增加有更强的贡献。但是，没有找到可靠的表达谱来预测抗辐射性。

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