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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Human papillomavirus and oropharynx cancer: biology, detection and clinical implications.
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Human papillomavirus and oropharynx cancer: biology, detection and clinical implications.

机译：人乳头瘤病毒和口咽癌：生物学，检测和临床意义。

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OBJECTIVES: To review evidence for the role of human papillomavirus (HPV) in the etiology of oropharyngeal cancers, methods of viral detection, and the resulting clinical implications. STUDY DESIGN: Contemporary review. METHODS: Published journal articles identified through PubMed and conference proceedings were reviewed. RESULTS: HPV-associated squamous cell carcinomas represent a distinct disease entity from carcinogen-associated squamous cell carcinomas. HPV oncoproteins lead to mucosal cell transformation through well-defined mechanisms. Different methods of detecting HPV exist with variable levels of sensitivity and specificity for biologically active virus. Although virus is detected in a number of head and neck subsites, studies demonstrate improved outcomes in HPV-associated carcinoma of the oropharynx only. The cell cycle regulatory protein p16 is upregulated by biologically active HPV and serves as a biomarker of improved response to therapy. CONCLUSIONS: HPV-associated squamous cell carcinoma of the oropharynx is a biologically distinct entity from carcinogen-associated carcinoma. Understanding the molecular mechanisms behind the improved outcomes in patients with HPV-associated oropharyngeal carcinoma may lead to novel therapeutics for patients with carcinogen-associated carcinomas.
机译：目的：回顾人类乳头瘤病毒（HPV）在口咽癌病因，病毒检测方法及其所产生的临床意义中的作用的证据。研究设计：当代评论。方法：审查了通过PubMed识别的已发表期刊文章和会议记录。结果：HPV相关的鳞状细胞癌代表与致癌物相关的鳞状细胞癌不同的疾病实体。 HPV癌蛋白通过明确定义的机制导致粘膜细胞转化。存在多种检测HPV的方法，它们对生物活性病毒的敏感性和特异性水平各不相同。尽管在许多头颈部亚位点都检测到病毒，但研究表明，仅在HPV相关的口咽癌中预后有所改善。细胞周期调节蛋白p16被具有生物活性的HPV上调，并作为治疗反应改善的生物标志物。结论：口咽部HPV相关鳞状细胞癌与致癌物相关癌是生物学上不同的实体。了解与HPV相关的口咽癌患者改善预后的分子机制可能会为与致癌物相关的癌症患者带来新的治疗方法。

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