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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Bisphosphonate-related osteonecrosis of the jaw and its associated risk factors: a Belgian case series.
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Bisphosphonate-related osteonecrosis of the jaw and its associated risk factors: a Belgian case series.

机译：双膦酸盐相关的颌骨坏死及其相关危险因素：比利时病例系列。

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OBJECTIVES: Bisphosphonate-related osteonecrosis of the jaw (BROJ) is a serious oral complication of bisphosphonate (BP) treatment involving the exposure of necrotic maxillary or mandibular bone. Our purpose is to describe the clinical presentation of 34 cases of BROJ and to identify potential risk factors. STUDY DESIGN: A retrospective study was performed in four Belgian institutions. METHODS: Complete medical histories were recorded and analyzed. These data include age, gender, initial disease requiring BP, type and duration of BP treatment, symptomatology and location of BROJ, prior dental procedures, treatment of the BROJ and treatment outcome, and radiographic, histological, and microbiological data. RESULTS: Bisphosphonates (BP) were used in the management of disseminated cancers in 30 patients (88.5% of total studied), while four patients received BP due to osteoporosis (11.5%). The most frequently used BP was zoledronic acid in 29 patients (83%). Microbiological data obtained in 25 patients demonstrated that 72% of these patients were infected or colonized by an actinomyces. Eight of the 14 patients (57%) who received only medical treatment were cured. Of the 20 patients who underwent surgical treatments, only four were completely cured (20%). BROJ lesions smaller than 1 cm are associated with better prognosis in terms of treatment outcomes (P = .0009). Local treatments combined with long-term antibiotics are also correlated with better prognosis (P = .02). CONCLUSIONS: Lesions smaller than 1 cm and lesions that were subject to medical treatments are associated with a better outcome. Surgical treatments appear to be non-beneficial for BROJ.
机译：目的：双膦酸盐相关的颌骨坏死（BROJ）是双膦酸盐（BP）治疗的严重口腔并发症，涉及坏死的上颌骨或下颌骨暴露。我们的目的是描述34例BROJ的临床表现并确定潜在的危险因素。研究设计：在四个比利时机构进行了一项回顾性研究。方法：记录并分析完整的病史。这些数据包括年龄，性别，需要BP的初始疾病，BP治疗的类型和持续时间，BROJ的症状和位置，以前的牙科手术，BROJ的治疗和治疗结果，以及射线照相，组织学和微生物学数据。结果：双膦酸盐（BP）用于治疗30例散发性癌症（占研究总数的88.5％），而四名因骨质疏松而接受BP治疗的患者（11.5％）。 29位患者（83％）中最常用的血压是唑来膦酸。 25名患者获得的微生物学数据表明，其中有72％的患者被放线菌感染或定殖。仅接受药物治疗的14例患者中有8例（57％）已治愈。在接受手术治疗的20例患者中，只有4例完全治愈（20％）。在治疗结果方面，小于1 cm的BROJ病变与更好的预后相关（P = .0009）。局部治疗结合长期抗生素治疗也与预后更好相关（P = .02）。结论：小于1 cm的病变和接受药物治疗的病变具有更好的预后。手术治疗似乎对BROJ无益。

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