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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Photodynamic therapy and the treatment of head and neck neoplasia.
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Photodynamic therapy and the treatment of head and neck neoplasia.

机译：光动力疗法和头颈部肿瘤的治疗。

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OBJECTIVE: To present the theory, technique, and results of photodynamic therapy for the treatment of oral, laryngeal, and head and neck cancers. STUDY DESIGN: Retrospective review of the literature of more than 500 patients with head and neck cancer treated with photodynamic therapy, as well as a retrospective review of the author's 107 patients treated with photodynamic therapy for head and neck neoplasia between 1990 and 1997. METHODS: The literature was retrospectively reviewed, as were patient records, and tabulated for age, sex, site, and staging of lesions, with special focus on post-photodynamic therapy treatment outcome, long-term disease-free survival, and complications. RESULTS: Twenty-five patients with carcinoma in situ and T1 squamous cell carcinoma of the true vocal cord who underwent photodynamic therapy treatment for cure obtained a complete response after a single photodynamic therapy treatment. Only one patient has had recurrence to date, with a cure rate to 79-month follow-up of 95%. Twenty-nine patients with carcinoma in situ and T1 recurrent squamous cell carcinomas of the oral cavity and tongue were treated. All obtained a complete response after a single photodynamic therapy treatment; however, five patients developed local recurrence with follow-up to 70 months, for an 80% cure rate. A review of 217 patients with early squamous cell carcinomas of the head and neck treated with photodynamic therapy in the literature demonstrated an 89.5% complete response rate. The most common complication in these patients was limited prolonged skin photosensitivity without any permanent sequelae. CONCLUSIONS: Photodynamic therapy is effective for treating carcinoma in situ and T1 squamous cell carcinoma of the larynx and oral cavity and may be of benefit as an adjuvant intraoperative treatment of stages III and IV tumors of the head and neck in conjunction with surgery and radiation therapy to improve cure rates. Further controlled studies need to be performed to further demonstrate the effectiveness of photodynamic therapy and the treatment of head and neck cancers.
机译：目的：介绍光动力疗法治疗口腔癌，喉癌和头颈癌的理论，技术和结果。研究设计：回顾性回顾性回顾了1990到1997年间用光动力疗法治疗的500例头颈癌患者的文献，以及回顾作者的107例光动力疗法治疗的头颈部肿瘤的患者的方法。回顾性回顾文献，包括患者记录，并按年龄，性别，部位和病变分期列表，特别关注光动力疗法后的治疗结果，长期无病生存和并发症。结果：25例原位癌和T1真声带鳞状细胞癌患者接受了光动力疗法的治愈后，单次光动力疗法就得到了完全缓解。迄今为止只有一名患者复发，至79个月的随访治愈率为95％。治疗了29例原位癌和T1复发性口腔和舌鳞状细胞癌患者。在一次光动力疗法治疗后，所有患者均获得了完全缓解;但是，有5位患者在随访70个月后出现了局部复发，治愈率为80％。文献对光动力疗法治疗的217例早期头颈部鳞状细胞癌患者的回顾显示，其总缓解率为89.5％。在这些患者中最常见的并发症是长期的皮肤光敏性有限，没有任何永久性后遗症。结论：光动力疗法可有效治疗喉和口腔的原位癌和T1鳞状细胞癌，结合外科手术和放射疗法，可作为术中辅助治疗头颈部III和IV期肿瘤的有益方法提高治愈率。需要进行进一步的对照研究，以进一步证明光动力疗法和头颈癌治疗的有效性。

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