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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Outcomes of primary surgical treatment of T1 and T2 carcinomas of the oropharynx.
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Outcomes of primary surgical treatment of T1 and T2 carcinomas of the oropharynx.

机译：口咽部T1和T2癌的主要外科治疗结果。

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OBJECTIVES: Oropharyngeal cancers represent 10%-15% of all head and neck cancers. At presentation 60%-70% will have advanced-stage disease with a high incidence of neck metastases. Primary treatment employing radiotherapy, with or without chemotherapy, is widely prescribed. The aim of this study is to analyze the outcome of definitive surgical management of T1-T2 cancers of the oropharynx. METHODS: We conducted a retrospective cohort study of patients treated at the Sydney Head and Neck Cancer Institute. Patients with previously untreated squamous cell carcinoma (SCC) of the oropharynx were included according to the TNM stage of the disease as follows: T1 or T2, any N-stage, and M0. All patients underwent definitive primary surgical management. Primary analysis endpoints were locoregional control rates and disease-specific survival. RESULTS: Ninety-two patients were identified, of which 26 were T1 and 66 were T2. Forty-four patients had clinical neck disease, and 57 had postoperative radiotherapy. The results showed no significant difference between the T1 and T2 groups with respect to local control or treatment type; however, advanced-stage neck disease was associated with a worse prognosis. The 5-year disease-specific survival was 83% and local control rate was 87%. Ultimately, 25 of the 92 patients had treatment failure (27%). CONCLUSIONS: Selected patients with early-stage primary cancers of the oropharynx may be effectively treated with definitive primary surgery.
机译：目的：口咽癌占所有头颈癌的10％-15％。演讲时，60％-70％的患者将患有晚期疾病，且颈部转移发生率很高。广泛规定了采用放疗的主要治疗方法，可以选择是否进行化疗。这项研究的目的是分析口咽T1-T2癌的明确外科治疗结果。方法：我们对悉尼头颈癌研究所治疗​​的患者进行了回顾性队列研究。根据疾病的TNM分期，包括先前未经治疗的口咽鳞状细胞癌（SCC）患者：T1或T2，任何N分期和M0。所有患者均接受了明确的初次手术治疗。主要分析终点为局部区域控制率和疾病特异性生存率。结果：确定了92例患者，其中T1 26例，T2 66例。四十四例患有临床颈部疾病，其中五十七例接受了术后放疗。结果显示，T1和T2组在局部控制或治疗类型方面无显着差异;然而，晚期颈部疾病预后较差。 5年疾病特异性存活率为83％，局部控制率为87％。最终，这92名患者中有25名治疗失败（27％）。结论：选定的患有早期口咽癌的患者可以通过明确的初次手术有效治疗。

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