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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Different biofilms, different disease? A clinical outcomes study.
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Different biofilms, different disease? A clinical outcomes study.

机译：不同的生物膜，不同的疾病？临床结果研究。

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OBJECTIVES/HYPOTHESIS: A potential role for biofilms in Chronic Rhinosinusitis (CRS) has been proposed, and the adverse impact they have on disease severity and postoperative outcomes has also been well described. Recent advances have allowed the species within the biofilms of CRS patients to be clearly characterized. This study investigates whether different biofilm species have different disease outcomes. STUDY DESIGN: Retrospective review. METHODS: Twenty-four patients with medically recalcitrant CRS undergoing Endoscopic Sinus Surgery (ESS), in whom we had previously characterized their biofilms using fluorescence in situ hybridization (FISH), were reviewed a median of 11 months after their surgery. They were evaluated for preoperative disease markers and evidence of on-going disease in the postoperative period. RESULTS: Thirty-seven biofilms were identified in the 24 patients. Almost half had polymicrobial biofilms. The presence of polymicrobial, rather than single-species biofilms adversely affected preoperative disease severity but did not alter postsurgical outcome. Patients with single organism Haemophilus influenzae biofilms presented with mild disease symptomatically and radiologically and achieved normal mucosa a short time after their surgery. Conversely, patients with Staphlococcus aureus in their biofilm makeup had more severe disease and a more complicated postoperative course. The effect of Pseudomonas aeruginosa and fungal biofilms is less clear. CONCLUSIONS: Different biofilm species are associated with different disease phenotypes. H. influenzae biofilms are typically found in patients with mild disease, whereas S. aureus is associated with a more severe, surgically recalcitrant pattern.
机译：目的/假设：已提出生物膜在慢性鼻-鼻窦炎（CRS）中的潜在作用，并且也已对生物膜对疾病严重程度和术后预后的不利影响进行了描述。最近的进展已使CRS患者生物膜内的物种得以清晰表征。这项研究调查了不同的生物膜物种是否具有不同的疾病结局。研究设计：回顾性审查。方法：对二十四名接受内镜鼻窦手术（ESS）的顽固性CRS的患者进行了回顾性分析，他们在中位手术后的11个月中均接受了荧光原位杂交（FISH）对其生物膜进行表征。对他们进行了术前疾病指标评估以及术后病情持续的证据。结果：24例患者中发现了37个生物膜。几乎一半有微生物生物膜。多种微生物而不是单一物种的生物膜的存在对术前疾病的严重程度产生不利影响，但并没有改变术后结果。带有单一生物体流感嗜血杆菌生物膜的患者在症状和影像学上均表现出轻度疾病，并且在手术后不久就达到了正常的粘膜。相反，生物膜成分中有金黄色葡萄球菌的患者病情更严重，术后病程也更复杂。铜绿假单胞菌和真菌生物膜的作用尚不清楚。结论：不同的生物膜种类与不同的疾病表型有关。流感嗜血杆菌生物膜通常在轻度疾病患者中发现，而金黄色葡萄球菌则伴有更严重的手术难治性模式。

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