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首页> 外文期刊>The American Journal of Cardiology >Impact of family hypertension history on exercise-induced cardiac remodeling.
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Impact of family hypertension history on exercise-induced cardiac remodeling.

机译：家庭高血压病史对运动引起的心脏重塑的影响。

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摘要

Left ventricular (LV) hypertrophy is a well-established, but highly variable, finding among exercise-trained persons. The causes for the variability in LV remodeling in response to exercise training remain incompletely understood. The present study sought to determine whether a family history of hypertension is a determinant of the cardiac response to exercise training. The cardiac parameters in 60 collegiate rowers (30 men/30 women; age 19.8 +/- 1.1 years) with (family history positive [FH+], n = 22) and without (family history negative [FH-], n = 38) a FH of hypertension were studied with echocardiography before and after 90 days of rowing training. The LV mass increased significantly in both groups. However, the LV mass increased significantly more in FH- persons (Delta 17 +/- 5 g/m(2)) than in FH+ persons (Delta 9 +/- 6 g/m(2), p <0.001) with distinctly differently patterns of LV hypertrophy between the 2 groups. FH- athletes experienced eccentric LV hypertrophy (relative wall thickness index 0.39 +/- 0.4) characterized by LV dilation. In contrast, FH+ athletes developed concentric LV hypertrophy (relative wall thickness index 0.44 +/- 0.3; p <0.001) characterized by LV wall thickening. Furthermore, the eccentric LV remodeling in FH- athletes was associated with a more robust enhancement of LV diastolic function than the concentric LV remodeling that occurred in FH+ athletes. In conclusion, these findings suggest that patterns of exercise-induced LV remodeling are strongly associated with FH history status.
机译：左心室肥大是一项行之有效的方法，但变化很大，在运动训练的人中发现。左心室重塑响应运动训练变化的原因仍不完全清楚。本研究试图确定高血压家族史是否是运动训练后心脏反应的决定因素。 60名大学赛艇运动员（30名男性/ 30名女性; 19.8 +/- 1.1岁）的心脏参数，有（家族史阳性[FH +]，n = 22）和没有（家族史阴性[FH-]，n = 38）在划船训练90天之前和之后，通过超声心动图研究高血压的FH。两组的左室重量明显增加。但是，FH人的左心室质量增加明显（Delta 17 +/- 5 g / m（2））比FH +人的左心室质量增加（Delta 9 +/- 6 g / m（2），p <0.001）明显。两组之间的LV肥大模式不同。 FH运动员经历了以LV扩张为特征的偏心LV肥大（相对壁厚指数0.39 +/- 0.4）。相比之下，FH +运动员发展了以LV壁增厚为特征的同心LV肥大（相对壁厚指数0.44 +/- 0.3; p <0.001）。此外，与FH +运动员中发生的同心LV重塑相比，FH运动员中的偏心LV重塑与LV舒张功能的增强更可靠。总之，这些发现表明，运动诱发的左室重塑的模式与FH病史状态密切相关。

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