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首页> 外文期刊>The American Journal of Cardiology >Usefulness of Triglycerides-to-High-Density Lipoprotein Cholesterol Ratio for Predicting the First Coronary Event in Men
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Usefulness of Triglycerides-to-High-Density Lipoprotein Cholesterol Ratio for Predicting the First Coronary Event in Men

机译：甘油三酸酯与高密度脂蛋白胆固醇比在预测男性首例冠状动脉事件中的作用

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摘要

Overweight and obesity potentiate the development of cardiovascular risk factors but many doubts have arisen recently regarding their role in coronary events. We evaluated the predictive value of a surrogate maker of insulin resistance, the ratio of triglyceride (TG) to high-density lipoprotein (HDL), for the incidence of a first coronary event in men workers according to body mass index (BMI). We designed a case-control study of active subjects collected from a single factory through their annual health examination and medical reports. Case subjects included those with myocardial infarction, unstable angina pectoris, or subclinical myocardial ischemia detected through electrocardiographic abnormalities. The sample was constituted by 208 case and 2,080 control subjects (mean age 49.9 years, 49.6 to 50.2). General characteristics of case and control subjects were well matched. The TG/HDL ratio was significantly higher in case subjects compared to controls. Stratification of the sample revealed an increasing prevalence of case subjects and mean TG/HDL in each category of BMI. Multivariable analysis, adjusted by smoking, demonstrated that TG/HDL increased 50% the risk of a first coronary event (odds ratio [OR] 1.47, 95% confidence interval [CI] 1.26 to 1.71), whereas low-density lipoprotein cholesterol values indicated a more moderate increased risk (OR 1.01, 95% CI 1.005 to 1.012); metabolic syndrome (OR 1.76, 95% CI 0.94 to 3.30) and hypertension (OR 1.50, 95% CI 0.81 to 2.79) did not reach statistical significance. The TG/HDL ratio was associated with a first coronary event in all categories of BMI. In conclusion, the TG/HDL ratio has a high predictive value of a first coronary event regardless of BMI.
机译：超重和肥胖加剧了心血管危险因素的发展，但是最近人们对它们在冠心病中的作用产生了许多疑问。我们根据体重指数（BMI）评估了胰岛素抵抗的替代制造商（甘油三酸酯（TG）与高密度脂蛋白（HDL）的比率）对于男性工作者中首例冠状动脉事件的预测价值。我们设计了一项病例对照研究，研究对象是从一家工厂通过年度健康检查和医疗报告收集来的。病例对象包括通过心电图异常检测出的患有心肌梗塞，不稳定型心绞痛或亚临床心肌缺血的患者。该样本由208例病例和2080例对照受试者组成（平均年龄49.9岁，从49.6至50.2）。病例和对照对象的一般特征完全匹配。与对照组相比，病例受试者的TG / HDL比明显更高。样本分层显示，在BMI的每个类别中，案例受试者和平均TG / HDL的患病率均在上升。通过吸烟进行调整的多变量分析表明，TG / HDL使首次冠心病的风险增加了50％（几率[OR] 1.47，95％置信区间[CI] 1.26至1.71），而低密度脂蛋白胆固醇值表明风险增加幅度较小（OR 1.01，95％CI 1.005至1.012）;代谢综合征（OR 1.76，95％CI 0.94至3.30）和高血压（OR 1.50，95％CI 0.81至2.79）没有统计学意义。 TG / HDL比值与所有BMI类别中的首次冠状动脉事件相关。总之，TG / HDL比值与BMI无关，对首次冠脉事件具有较高的预测价值。

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