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首页> 外文期刊>The American Journal of Cardiology >Relation of Combined Non-High-Density Lipoprotein Cholesterol and Apolipoprotein B With Atherosclerosis in Adults With Type 1 Diabetes Mellitus
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Relation of Combined Non-High-Density Lipoprotein Cholesterol and Apolipoprotein B With Atherosclerosis in Adults With Type 1 Diabetes Mellitus

机译：成人1型糖尿病患者非高密度脂蛋白胆固醇和载脂蛋白B联合与动脉粥样硬化的关系

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Apolipoprotein B (apoB) and non high-density lipoprotein cholesterol (non-HDL-C) are cardiovascular disease risk markers, although data in adults with type 1 diabetes mellitus (DM) are limited. We hypothesized that elevated apoB and non-HDL-C would be associated with greater odds of coronary artery calcification progression (CACp), a measure of coronary atherosclerosis, than either category alone in adults with type 1 DM. We grouped subjects with type 1 DM (n = 652) into 4 groups: elevated apoB (>= 90 mg/dl) and elevated non-HDL-C (>= 1.30 mg/dl), elevated non-HDL-C alone, elevated apoB alone, and normal apoB and non-HDL-C. We used logistic regression to examine the associations between the groups and CACp for a period of 6 years. We performed sensitivity analyses with elevated apoB and non-HDL-C redefined as at or more than the cohort means (91.4 and 119.0 mg/dl, respectively). Subjects with elevated apoB and non-HDL-C had greater odds of CACp compared with those with normal apoB and non-HDL-C (odds ratio 1.90, 95% confidence interval 1.15 to 3.15) and compared with subjects with elevated apoB alone (odds ratio 2.86, 95% confidence interval 1.43 to 5.74) adjusting for age, gender, duration, hemoglobin A1c, and stains. Similar results were obtained with elevated apoB and non-HDL-C defined as at or more than the cohort means. In conclusion, elevated apoB and non-HDL-C carry a greater risk of atherosclerosis than elevated apoB in the absence of elevated non-HDL-C in adults with type 1 DM. These data suggest that apoB and non-HDL-C should be viewed as complementary rather than competitive indexes of cardiovascular disease risk in type 1 DM. (C) 2015 Elsevier Inc. All rights reserved.
机译：载脂蛋白B（apoB）和非高密度脂蛋白胆固醇（non-HDL-C）是心血管疾病的危险指标，尽管成人1型糖尿病（DM）的数据有限。我们假设升高的apoB和非HDL-C与1型DM成年人中单独的任一类别相比，冠状动脉钙化进展（CACp）（一种衡量冠状动脉粥样硬化的指标）的可能性更高。我们将1型糖尿病（n = 652）的受试者分为4组：apoB升高（> = 90 mg / dl）和非HDL-C升高（> = 1.30 mg / dl），单独的非HDL-C升高，单独的apoB升高，以及正常的apoB和非HDL-C升高。我们使用logistic回归研究了6年期间各组与CACp之间的关联。我们进行了敏感性分析，其中升高的apoB和非HDL-C重新定义为等于或高于同类平均水平（分别为91.4和119.0 mg / dl）。载脂蛋白B和非HDL-C升高的受试者与正常载脂蛋白B和非HDL-C的受试者相比（机会比1.90,95％置信区间1.15至3.15）和单独使用载脂蛋白B升高的受试者相比（可能性高）比例为2.86，95％置信区间为1.43至5.74），并根据年龄，性别，病程，血红蛋白A1c和污渍进行了调整。用升高的apoB和非HDL-C定义为等于或大于同类队列均获得了相似的结果。总之，在没有1型DM成年人的非HDL-C升高的情况下，升高的apoB和非HDL-C的动脉粥样硬化风险要高于升高的apoB。这些数据表明，apoB和非HDL-C应被视为1型DM心血管疾病风险的互补而非竞争指标。 （C）2015 Elsevier Inc.保留所有权利。

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