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首页> 外文期刊>The American Journal of Cardiology >Anemia for risk assessment of patients with acute coronary syndromes.
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Anemia for risk assessment of patients with acute coronary syndromes.

机译：贫血用于急性冠脉综合征患者的风险评估。

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In patients admitted with acute coronary syndromes, those with anemia are at higher risk. However, current risk score systems do not take into account the presence of anemia. The impact of anemia on mortality was studied, and its incremental predictive value was evaluated. Demographic, clinical, and biologic characteristics at admission, as well as treatments and mortality, were recorded for 1,410 consecutive patients with acute coronary syndromes. The incremental value of adding anemia information to risk score evaluation was determined using changes in the appropriateness of Cox models when anemia was added. Anemia was detected in 381 patients (27%). They were older, had more co-morbidities, had higher Global Registry of Acute Coronary Events (GRACE) risk scores, received fewer guideline-recommended treatments, and, as a result, had 4-fold higher mortality. When included in a prediction model based on the GRACE risk score, anemia remained an independent predictor of mortality. The addition of anemia improved both the discriminatory capacity and calibration of the models. According to the GRACE risk score, the population was divided into 4 groups of different risk levels of <1%, 1% to <5%, 5% to <10%, and > or =10%. The addition of anemia to the model made it possible to reclassify 9%, 43%, 47%, and 23% of patients into the different risk categories, respectively. In conclusion, our data confirmed that anemia was an independent predictive factor of mortality and had incremental predictive value to the GRACE score system for early clinical outcomes.
机译：在患有急性冠脉综合征的患者中，贫血患者的风险更高。但是，当前的风险评分系统并未考虑贫血的存在。研究了贫血对死亡率的影响，并评估了其增加的预测价值。记录了1,410例连续的急性冠脉综合征患者的入院时的人口统计学，临床和生物学特征以及治疗和死亡率。在添加贫血时，使用Cox模型适用性的变化来确定将贫血信息添加到风险评分评估中的增量值。在381例患者中检测到贫血（27％）。他们年龄较大，合并症较多，急性冠脉事件全球登记系统（GRACE）风险评分较高，指南推荐的治疗方法较少，因此死亡率高4倍。如果将其纳入基于GRACE风险评分的预测模型中，则贫血仍然是死亡率的独立预测因子。贫血的增加改善了模型的判别能力和校准能力。根据GRACE风险评分，将人群分为4组，其不同风险水平分别为<1％，1％至<5％，5％至<10％，以及>或= 10％。将贫血加到模型中可以分别将9％，43％，47％和23％的患者重新分类为不同的风险类别。总之，我们的数据证实了贫血是死亡率的独立预测因素，对GRACE评分系统的早期临床结果具有递增的预测价值。

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