Effect of acute myocardial infarction on erythrocytic glutathione peroxidase 1 activity and plasma vitamin e levels.

Cheng ML; Chen CM; Ho HY; Li JM; Chiu DT

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Effect of acute myocardial infarction on erythrocytic glutathione peroxidase 1 activity and plasma vitamin e levels.

机译：急性心肌梗塞对红细胞谷胱甘肽过氧化物酶1活性和血浆维生素e水平的影响。

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Glutathione peroxidase 1 (GPX-1) has an important role in antioxidant defense and has been suggested to have a protective role against the pathogenesis of atherosclerosis. In the present study, erythrocytic GPX-1 activity from 42 patients with acute myocardial infarction and 285 healthy control subjects of Taiwanese origin were determined. Our data showed that mean GPX-1 activity decreased in patients with acute myocardial infarction (40.7 +/- 9.2 vs 47.3 +/- 16.6 U/g hemoglobin; p <0.001). There was a significant inverse correlation between GPX-1 activity and acute myocardial infarction incidence (p = 0.032). In addition, plasma vitamin E inversely correlated with acute myocardial infarction incidence (p = 0.017). The incidence of acute myocardial infarction increased only in patients with low plasma vitamin E and low erythrocytic GPX-1 activity, but not in those with high vitamin E and low GPX-1 activity, low vitamin E and high GPX-1 activity, or high vitamin E and high GPX-1 activity. In conclusion,acute myocardial infarction incidence significantly increased in patients with a concomitant decrease in plasma vitamin E and erythrocytic GPX-1 activity, suggesting that both GPX-1 and vitamin E may be valuable markers for monitoring cardiovascular events, particularly when used in combination.

机译：谷胱甘肽过氧化物酶1（GPX-1）在抗氧化剂防御中具有重要作用，并被认为对动脉粥样硬化的发病具有保护作用。在本研究中，确定了42例急性心肌梗死患者和285名台湾血统健康对照者的红细胞GPX-1活性。我们的数据显示，急性心肌梗死患者的平均GPX-1活性降低（40.7 +/- 9.2 vs 47.3 +/- 16.6 U / g血红蛋白; p <0.001）。 GPX-1活性与急性心肌梗塞发生率之间呈显着负相关（p = 0.032）。此外，血浆维生素E与急性心肌梗死的发生率呈负相关（p = 0.017）。仅在血浆维生素E低和红细胞GPX-1活性低的患者中，急性心肌梗塞的发生率增加，而维生素E高和GPX-1活性低，维生素E和GPX-1活性高或高的患者则不增加。维生素E和高GPX-1活性。总之，血浆维生素E和红细胞GPX-1活性同时下降的患者急性心肌梗塞发生率显着增加，这表明GPX-1和维生素E可能是监测心血管事件的有价值的标志物，尤其是组合使用时。

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《The American Journal of Cardiology》 |2009年第4期|共5页
作者
Cheng ML; Chen CM; Ho HY; Li JM; Chiu DT;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Aged; Case-Control Studies; Erythrocytes; Female; Glutathione Peroxidase; 老年人; 病例对照研究; 红细胞; 谷胱甘肽过氧化酶; 发病率; 心肌梗塞; 台湾; 维生素E;

机译：Aged;Case-Control Studies;Erythrocytes;Female;Glutathione Peroxidase;老年人;病例对照研究;红细胞;谷胱甘肽过氧化酶;发病率;心肌梗塞;台湾;维生素E;

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专利

1. Effect of acute myocardial infarction on erythrocytic glutathione peroxidase 1 activity and plasma vitamin e levels. [J] . Cheng ML, Chen CM, Ho HY, The American Journal of Cardiology . 2009,第4期

机译：急性心肌梗塞对红细胞谷胱甘肽过氧化物酶1活性和血浆维生素e水平的影响。
2. Selenium levels and glutathione peroxidase activities in patients with acute myocardial infarction. [J] . Bor MV, Cevik C, Uslu I, Acta Cardiologica . 1999,第5期

机译：急性心肌梗死患者的硒水平和谷胱甘肽过氧化物酶活性。
3. Glutathione Peroxidase Activity in Serum during Acute Myocardial Infarction and Unstable Angina Pectoris [J] . ?mer AKYOL, Orhan SENCAN, Süleyman BüYüKBERBER, Japanese heart journal . 1993,第5期

机译：急性心肌梗死和不稳定型心绞痛期间血清谷胱甘肽过氧化物酶活性
4. Clinical and biochemical factors associated with acute myocardial infarction: Risk factors for acute myocardial infarction [C] . Sounira Mehri, Mohamed Hammami International Conference on Engineering MIS . 2017

机译：与急性心肌梗死相关的临床和生化因素：急性心肌梗死的危险因素
5. Association of 25-hydroxy vitamin D deficiency with NT-pro BNP levels in acute myocardial infarction patients. [D] . Gadi, Rajyalakshmi. 2010

机译：急性心肌梗死患者中25-羟基维生素D缺乏与NT-pro BNP水平的相关性。
6. Non-invasive diagnosis of infarct artery patency after acute myocardial infarction by use of serial plasma troponin T concentrations: importance of measurement of peak levels. [O] . R. M. Norris, R. N. Johnson, H. D. White, 1996

机译：通过使用系列血浆肌钙蛋白T浓度进行非侵入性诊断急性心肌梗死后梗死动脉通畅：峰值水平测量的重要性。
7. Six practical diets were formulated to contain 2.6 (the basal diet), 48.9, 95.5, 189.83, 382.4, 779.53 mg/kg vitamin C diet. After 8 weeks of feeding, growth performance, antioxidant status, and innate immunity of juvenile pufferfish were analyzed. Results showed that specific growth rate and protein efficiency ratio in fish fed diets supplemented with vitamin C were significantly higher than in fish fed the control diet. Dietary vitamin C significantly up-regulated the expression levels of growth hormone receptors and Insulin-like growth factor. Blood cell numbers and respiratory burst activity were enhanced in fish fed vitamin C diet. Serum alkaline phosphatase, glutamic-pyruvic transaminase, and glutamic-oxaloacetic transaminase activity were significantly influenced by the dietary vitamin C levels. Fish fed diets supplemented with vitamin C showed increased hepatic superoxide dismutase, glutathione peroxidase, and catalase activity, but decreased malondialdehyde activity. In addition, we found that dietary vitamin C can significantly up-regulate the expression levels of immune-related genes (HSP70, HSP90, BAFF, TNF-α and IL-6) in liver. These results indicate that dietary vitamin C can significantly influence growth performance, antioxidant status, and innate immunity of pufferfish. [O] . Cheng C-H, Liang H-Y., Guo Z-X., 2017

机译：配制了六种实用饮食，分别含有2.6（基础饮食），48.9、95.5、189.83、382.4、779.53 mg / kg维生素C饮食。喂食8周后，分析了幼崽河豚的生长性能，抗氧化剂状态和先天免疫力。结果表明，补充维生素C的鱼饲料的比生长速率和蛋白质效率比显着高于对照组的鱼。饮食中的维生素C显着上调了生长激素受体和胰岛素样生长因子的表达水平。喂鱼的维生素C饮食可提高血细胞数量和呼吸爆发活性。饮食中的维生素C水平显着影响血清碱性磷酸酶，谷氨酸-丙酮酸转氨酶和谷氨酸-草酰乙酸转氨酶的活性。补充维生素C的鱼饲料日粮中肝超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶活性增加，但丙二醛活性降低。此外，我们发现饮食中的维生素C可以显着上调肝脏中免疫相关基因（HSP70，HSP90，BAFF，TNF-α和IL-6）的表达水平。这些结果表明，饮食中的维生素C可以显着影响河豚的生长性能，抗氧化状态和先天免疫力。

Effect of acute myocardial infarction on erythrocytic glutathione peroxidase 1 activity and plasma vitamin e levels.

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