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首页> 外文期刊>The American Journal of Cardiology >Relation of carotid intima-media thickness and aortic valve sclerosis (from the ISMIR study ('Ispessimento Medio Intimale e Rischio Cardiovascolare') of the Italian Society of Cardiovascular Echography).
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Relation of carotid intima-media thickness and aortic valve sclerosis (from the ISMIR study ('Ispessimento Medio Intimale e Rischio Cardiovascolare') of the Italian Society of Cardiovascular Echography).

机译：颈动脉内膜中层厚度与主动脉瓣硬化之间的关系（来自意大利心血管电图学会的ISMIR研究（“ Ispessimento Medio Intimale e Rischio Cardiovascolare”）。

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Carotid intima-media thickness (IMT) and aortic valve sclerosis (AVS) have recently emerged as important predictive factors for cardiovascular (CV) events. However, few data are available on their association and the respective roles of major CV risk factors in determining either condition. In this study, 479 asymptomatic subjects (mean age 58 +/- 13 years, 62% men) were assessed, without histories of CV disease, consecutively referred for comprehensive evaluations by echocardiography and carotid ultrasonography because of the presence of > or = 1 risk factor. Common carotid artery IMT and aortic valve morphology and function were analyzed. The mean IMT was 0.82 +/- 0.19 mm. The prevalence of increased carotid IMT (>0.80 mm) and AVS was 60.8% and 18.4%, respectively. The prevalence of increased IMT was 79.6% in subjects with AVS and 56.5% in those without AVS (relative risk 2.99, 95% confidence interval 1.72 to 5.21, p <0.001). On multivariate analysis, increased IMT was significantly and independently associated with hypertension, dyslipidemia, obesity, family history of CV disease, and age. Only age emerged as an independent predictor of AVS. The presence of both markers was independently associated only with hypertension and age. In conclusion, increased carotid IMT was strongly associated with AVS in a population of asymptomatic patients. IMT and AVS were differently related to individual CV risk factors, and their association seems to be correlated mainly with age and hypertension.
机译：颈动脉内膜中层厚度（IMT）和主动脉瓣硬化（AVS）最近已成为心血管（CV）事件的重要预测因素。但是，关于它们的关联以及主要CV风险因素在确定任何一种情况中的各自作用的数据很少。在这项研究中，评估了479名无症状受试者（平均年龄58 +/- 13岁，男性为62％），无CV病史，由于存在>或= 1风险，因此连续通过超声心动图和颈动脉超声检查进行综合评估因子。分析了颈总动脉IMT和主动脉瓣的形态和功能。平均IMT为0.82 +/- 0.19毫米。颈动脉IMT（> 0.80 mm）和AVS的患病率分别为60.8％和18.4％。患有AVS的受试者的IMT增加患病率为79.6％，而没有AVS的受试者的IMT增加率为56.5％（相对危险度2.99，95％置信区间1.72至5.21，p <0.001）。在多变量分析中，IMT增加与高血压，血脂异常，肥胖，CV病家族史和年龄显着且独立相关。只有年龄是AVS的独立预测因子。两种标记物的存在仅与高血压和年龄有关。总之，在无症状患者中，颈动脉IMT的增加与AVS密切相关。 IMT和AVS与个体CV危险因素的相关性不同，它们的关联似乎主要与年龄和高血压相关。

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