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首页> 外文期刊>The American Journal of Cardiology >Relation of corneal arcus to cardiovascular disease (from the Framingham Heart Study data set).
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Relation of corneal arcus to cardiovascular disease (from the Framingham Heart Study data set).

机译：角膜弧度与心血管疾病的关系（来自Framingham心脏研究数据集）。

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Corneal arcus is a lipid-rich deposit at the corneoscleral limbus that shares some similarities with the lipid deposition of atherosclerosis. Epidemiologic studies examining the association between corneal arcus and coronary artery disease (CAD) have yielded mixed results. This study was conducted to determine if corneal arcus is an independent risk factor for cardiovascular disease (CVD) and CAD. A prospective analysis was performed using Cox proportional-hazards regression models in the Framingham Heart Study Original Cohort and Offspring Cohort database. This cohort included 23,376 patient-examinations, during 3,890 (17%) of which corneal arcus was identified. Corneal arcus was a predictor of CVD and CAD at 4 years (hazard ratios [HRs] 2.28 and 1.99, respectively) and 8 years (HRs 2.52 and 2.35, respectively) of follow-up (p <0.0001 for all). Corneal arcus was no longer predictive of either CVD or CAD, however, after adjustment for age and gender at 4 years (HRs 1.07 and 1.01, respectively) and 8 years (HRs 1.18 and 1.17, respectively) of follow-up (p >0.05 for all). In conclusion, corneal arcus predicted CVD and CAD in the community-based Framingham Heart Study cohort because of the strong association of corneal arcus with increasing age. To date, this is the largest and lengthiest population-based cohort study examining the direct association between corneal arcus and CVD and CAD.
机译：角膜弧菌是角膜巩膜缘处富含脂质的沉积物，与动脉粥样硬化的脂质沉积有一些相似之处。流行病学研究检查了角膜弓和冠状动脉疾病（CAD）之间的关联，得出的结果好坏参半。进行这项研究是为了确定角膜弧度是否是心血管疾病（CVD）和CAD的独立危险因素。使用Framingham心脏研究原始队列和后代队列数据库中的Cox比例风险回归模型进行前瞻性分析。该队列包括23376例患者检查，其中3890例（17％）被确定为角膜弓状。随访4年（危险比[HRs]分别为2.28和1.99）和8年随访（HRs分别为2.52和2.35），角膜弧度是CVD和CAD的预测指标（所有患者均p <0.0001）。调整了年龄和性别后，在随访4年（分别为HRs 1.07和1.01）和8年（分别为HRs 1.18和1.17）后，角膜弧度不再能预测CVD或CAD（p> 0.05对全部）。总之，由于角膜弧度与年龄增长密切相关，因此基于社区的Framingham心脏研究队列预测了角膜弧度的CVD和CAD。迄今为止，这是最大的，最长的基于人群的队列研究，其研究了角膜弧度与CVD和CAD之间的直接关联。

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