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首页> 外文期刊>The American Journal of Cardiology >Relation between C-reactive protein, homocysteine levels, fibrinogen, and lipoprotein levels and leukocyte and platelet counts, and 10-year risk for cardiovascular disease among healthy adults in the USA.
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Relation between C-reactive protein, homocysteine levels, fibrinogen, and lipoprotein levels and leukocyte and platelet counts, and 10-year risk for cardiovascular disease among healthy adults in the USA.

机译：在美国健康成年人中，C反应蛋白，同型半胱氨酸水平，纤维蛋白原和脂蛋白水平与白细胞和血小板计数之间的关系以及心血管疾病的10年风险。

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摘要

The association between systemic inflammation and the estimated 10-year risk for coronary artery disease (CAD) according to the Framingham risk score is largely unknown. In this study, 6,371 participants in the Third National Health and Nutrition Examination Survey (NHANES III) aged 40 to 79 years, who had no histories of heart attack, stroke, peripheral artery disease, or diabetes mellitus, were categorized into groups at low (<10%), intermediate (10% to 20%), and high (>20%) risk according to 10-year risk for CAD, calculated using the Framingham risk score modified by the National Cholesterol Education Program Adult Treatment Panel III. After adjustments for age, gender, race, body mass index, and co-morbidities, participants at high risk were more likely to have elevated circulating C-reactive protein levels (>/=2.2 mg/L: adjusted odds ratio [OR] 1.61, 95% confidence interval [CI] 1.30 to 2.01, p <0.0001; >10.0 mg/L: OR 1.41, 95% CI 1.03 to 1.93, p = 0.034). The high-risk group had circulating fibrinogen, homocysteine, leukocyte, and platelet levels that were 20.98 mg/dl (95% CI 12.53 to 29.43, p <0.0001), 1.54 mumol/L (95% CI 0.76 to 2.32, p = 0.002), 0.90 mumol/L (95% CI 0.36 to 1.43, p = 0.001), 910/microl (95% CI 670 to 1,160, p <0.0001), and 10,220/microl (95% CI 2,830 to 17,610, p <0.0001) higher, respectively, than in those in the low-risk group. There was also a dose-dependent increase in circulating levels of inflammatory markers across the categories of CAD risk. In conclusion, these findings indicate that low-grade systemic inflammation and hyperhomocysteinemia were present in participants with high 10-year risk for CAD.
机译：根据Framingham风险评分，系统性炎症与估计的10年冠状动脉疾病（CAD）风险之间的关联尚不清楚。在这项研究中，第三次全国健康与营养调查（NHANES III）中的6371名年龄在40至79岁之间，没有心脏病发作，中风，外周动脉疾病或糖尿病史的参与者被分为低（根据由美国胆固醇教育计划成人治疗小组III修改的Framingham风险评分计算得出的CAD的10年风险，得出<10％），中等（10％至20％）和高（> 20％）风险。在调整了年龄，性别，种族，体重指数和合并症之后，高风险参与者更可能具有升高的循环C反应蛋白水平（> / = 2.2 mg / L：调整后的优势比[OR] 1.61 ，95％置信区间[CI] 1.30至2.01，p <0.0001;> 10.0 mg / L：或1.41，95％CI 1.03至1.93，p = 0.034）。高危组的循环血纤维蛋白原，同型半胱氨酸，白细胞和血小板水平分别为20.98 mg / dl（95％CI 12.53至29.43，p <0.0001），1.54 mumol / L（95％CI 0.76至2.32，p = 0.002 ），0.90 mumol / L（95％CI 0.36至1.43，p = 0.001），910 /微升（95％CI 670至1,160，p <0.0001）和10,220 / microl（95％CI 2,830至17,610，p <0.0001） ）分别比低风险组的收入高。在各种CAD风险类别中，炎症标志物的循环水平也呈剂量依赖性增加。总之，这些发现表明，患有10年高CAD风险的参与者存在低度全身性炎症和高同型半胱氨酸血症。

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