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首页> 外文期刊>The American Journal of Cardiology >Relation of plasma indoxyl sulfate levels and estimated glomerular filtration rate to left ventricular diastolic dysfunction
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Relation of plasma indoxyl sulfate levels and estimated glomerular filtration rate to left ventricular diastolic dysfunction

机译：血浆吲哚酚硫酸盐水平和估计的肾小球滤过率与左心室舒张功能障碍的关系

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摘要

The prognosis of patients with diastolic heart failure (HF) is as poor as that of patients with systolic HF. Greater chronic kidney disease-associated mortality occurs in patients with left ventricular (LV) diastolic HF than in those with systolic HF. Indoxyl sulfate (IS), a uremic toxin, directly affects cardiac cells adversely in in vitro experiments. We investigated the association of IS, a uremic toxin, and chronic kidney disease with LV diastolic dysfunction in the clinical setting. The present study included 204 consecutive patients with preserved LV systolic function. To evaluate LV function, all patients underwent echocardiography. To measure the plasma IS levels and estimated glomerular filtration rate (eGFR), blood samples were obtained. Of the 204 patients, 75 (37%) had LV diastolic dysfunction. A significantly lower prevalence of LV diastolic dysfunction was present in patients with lower plasma IS levels (??1.0 ??g/ml) than those with greater plasma IS levels (38 [29%] vs 37 [51%], p <0.001). Furthermore, a significantly lower prevalence of LV diastolic dysfunction was present in patients with lower plasma IS levels and preserved eGFR than those with greater plasma IS levels and preserved eGFR, those with lower plasma IS levels and a reduced eGFR, or those with greater plasma IS levels and reduced eGFR (20 [21%] vs 18 [53%], p = 0.001; 20 [21%] vs 18 [46%], p = 0.004; and 20 [21%] vs 19 [56%], p <0.001, respectively). In conclusion, greater plasma IS levels or a reduced eGFR, or both, represent an increased risk of LV diastolic dysfunction. ? 2013 Elsevier Inc. All rights reserved.
机译：舒张性心力衰竭（HF）患者的预后与收缩性HF一样差。左心室舒张期HF患者的慢性肾脏病相关死亡率要高于收缩期HF患者。硫酸吲哚酚硫酸盐（IS）是一种尿毒症毒素，在体外实验中直接对心脏细胞产生不利影响。我们调查了IS，一种尿毒症毒素和慢性肾脏疾病与LV舒张功能障碍的临床关系。本研究包括204例LV收缩功能保留的连续患者。为了评估左室功能，所有患者均接受了超声心动图检查。为了测量血浆IS水平和估计的肾小球滤过率（eGFR），获得了血液样本。在204例患者中，有75例（37％）患有LV舒张功能障碍。血浆IS水平较低的患者（?? 1.0 ?? g / ml）的血浆LV舒张功能障碍的患病率明显高于血浆IS水平较高的患者（38 [29％] vs 37 [51％]，p <0.001 ）。此外，血浆IS水平较低和eGFR保持水平较血浆IS水平较高和eGFR保持水平较高，血浆IS水平较低且eGFR降低或血浆IS水平较高的患者，左室舒张功能障碍的患病率明显降低。水平和降低的eGFR（20 [21％] vs 18 [53％]，p = 0.001; 20 [21％] vs 18 [46％]，p = 0.004; 20 [21％] vs 19 [56％]， p分别为<0.001）。总之，较高的血浆IS水平或降低的eGFR或两者均表示LV舒张功能障碍的风险增加。 ？ 2013 Elsevier Inc.保留所有权利。

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