...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Cardiology >Biomarkers and electrocardiographic evidence of myocardial ischemia in patients with human immunodeficiency virus infection
【24h】

Biomarkers and electrocardiographic evidence of myocardial ischemia in patients with human immunodeficiency virus infection

机译：人类免疫缺陷病毒感染患者心肌缺血的生物标志物和心电图证据

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We assessed the relation of inflammatory and coagulation biomarkers with electrocardiographic (ECG) evidence of myocardial ischemia. High-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and D-dimer levels were measured at study entry for 3,085 human immunodeficiency virus-infected participants (mean age 44 years; 26.4% women; 24.6% black) in the Strategies for Management of Antiretroviral Therapy trial. Logistic regression models were used to examine the associations of these biomarkers with prevalent and incident myocardial ischemia. The latter analyses were performed for 1,411 participants who were randomly assigned to receive continuous antiretroviral therapy during follow-up to suppress the human immunodeficiency virus viral load and had ??1 ECG reading during the follow-up period. The median hsCRP, IL-6, and D-dimer level was 1.65 ??g/ml (interquartile range 0.69 to 4.11), 1.60 pg/ml (interquartile range 1.00 to 2.75), and 0.18 ??g/ml (interquartile range 0.11 to 0.32), respectively. At baseline, the prevalence of major or minor Q-QS or ST-T ECG abnormalities was 18.6%. The biomarker levels were associated with prevalent major or minor ischemic abnormalities on the univariate analyses; however, adjustment for traditional risk factors attenuated these associations. The adjusted odds ratio for major or minor ischemic abnormalities and 95% confidence intervals for the greatest versus lowest quartiles was 1.3 (95% confidence interval 0.9 to 1.7) for hsCRP, 1.0 (95% confidence interval 0.7 to 1.3) for IL-6, and 1.1 (95% confidence interval 0.9 to 1.5) for D-dimer. During a median follow-up of 2.3 years, new definite or probable ischemic ECG abnormalities developed in 11.7% of participants receiving continuous antiretroviral therapy. Biomarker levels were not associated with incident abnormalities on unadjusted or adjusted analyses. In conclusion, higher levels of hsCRP, IL-6, and D-dimer were not associated with ischemic ECG abnormalities. Elevated biomarker levels and ECG abnormalities indicating myocardial ischemia might reflect different risk pathways for cardiovascular disease. ? 2013 Elsevier Inc. All rights reserved.
机译：我们评估了炎症和凝血生物标志物与心肌缺血的心电图（ECG）证据之间的关系。在研究入组时对3,085名人类免疫缺陷病毒感染的参与者（平均年龄44岁;女性26.4％; 24.6％）进行了高敏C反应蛋白（hsCRP），白介素6（IL-6）和D-二聚体水平测量。黑色）在“抗逆转录病毒疗法管理策略”试验中。使用逻辑回归模型检查这些生物标记物与普遍和事件性心肌缺血的相关性。对1,411名参与者进行了后者的分析，这些参与者在随访期间被随机分配接受连续抗逆转录病毒治疗，以抑制人类免疫缺陷病毒的病毒载量，并在随访期间获得?? 1 ECG读数。 hsCRP，IL-6和D-二聚体水平中位数为1.65 pg / ml（四分位数范围为0.69至4.11），1.60 pg / ml（四分位数范围为1.00至2.75）和0.18 pg / ml（四分位数为范围） 0.11至0.32）。在基线时，主要或次要Q-QS或ST-T ECG异常的患病率为18.6％。在单变量分析中，生物标志物水平与普遍的主要或次要缺血异常有关。然而，传统风险因素的调整减弱了这些关联。对于hsCRP，主要或次要缺血异常和最大四分位数与最低四分位数的95％置信区间的校正比值比为1.3（IL-6为1.0（95％置信区间0.7到1.3），即95％置信区间为0.9至1.7）， D-二聚体为1.1（95％置信区间0.9至1.5）。在2.3年的中位随访期间，接受持续抗逆转录病毒治疗的参与者中有11.7％出现了新的明确或可能的缺血性ECG异常。在未经调整或经过调整的分析中，生物标志物水平与事件异常无关。总之，高水平的hsCRP，IL-6和D-二聚体与缺血性ECG异常无关。指示心肌缺血的生物标志物水平和ECG异常升高可能反映了心血管疾病的不同危险途径。 ？ 2013 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号