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首页> 外文期刊>The American Journal of Cardiology >Prevalence of depression in patients with chest pain and non-obstructive coronary artery disease
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Prevalence of depression in patients with chest pain and non-obstructive coronary artery disease

机译：胸痛和非阻塞性冠状动脉疾病患者的抑郁症患病率

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Many studies have demonstrated the prevalence of depression in patients with coronary artery disease (CAD), but few have examined this relation in those with chest pain who do not have obstructive CAD on angiography. The aim of this study was to compare the prevalence of depression amongst patients with chest pain in the presence or absence of obstructive CAD and a healthy control group without chest pain. This prospectively designed, observational cohort study used 2 independent data sets: (1) The Queen Elizabeth Hospital Coronary Angiogram Database (n = 1,144), consisting of 819 patients with obstructive CAD and 325 patients with nonobstructive CAD (NoCAD), all of whom had chest pain and (2) the North West Adelaide Health Study (NWAHS; n = 3,168), a population-based biomedical cohort, from which patients with chest pain were excluded. The presence of depression was determined by a previously validated method using the Short Form 36. The prevalence of depression differed among the 3 groups, with 63% in those with NoCAD, 53% in those with CAD, and only 24% in the healthy NWAHS cohort. Analysis of the angiography cohort revealed age, gender, antidepressant medication, previous myocardial infarction, previous airway disease, Short Form 36 physical summary score, Seattle Angina Questionnaire physical limitation score, and NoCAD on angiography to be independent predictors of depression. In conclusion, these findings highlight the importance of screening for depression in patients with NoCAD.
机译：许多研究证明了冠心病（CAD）患者的抑郁症患病率，但很少有人对那些在血管造影术中没有阻塞性CAD的胸痛患者进行检查。这项研究的目的是比较存在或不存在阻塞性CAD的胸痛患者和没有胸痛的健康对照组的抑郁症患病率。这项前瞻性设计的观察性队列研究使用了2个独立的数据集：（1）伊丽莎白女王医院冠状动脉血管造影数据库（n = 1,144），由819例阻塞性CAD患者和325例非阻塞性CAD（NoCAD）患者组成，所有患者均胸痛;（2）西北阿德莱德健康研究（NWAHS; n = 3,168），这是一项基于人群的生物医学队列，其中不包括胸痛患者。抑郁症的存在是通过先前使用短表格36验证的方法确定的。三组患者的抑郁症患病率不同，其中NoCAD患者中63％，CAD患者中53％，健康NWAHS中仅24％队列。血管造影队列分析显示年龄，性别，抗抑郁药物，先前的心肌梗塞，先前的气道疾病，简短表格36体格综合评分，西雅图心绞痛问卷调查身体极限评分以及血管造影上的NoCAD是抑郁症的独立预测因子。总之，这些发现突出了筛查NoCAD患者抑郁症的重要性。

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