...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Cardiology >Comparison of outcomes for patients ≥75 years of age treated with pre-hospital reduced-dose fibrinolysis followed by percutaneous coronary intervention versus percutaneous coronary intervention alone for treatment of st-elevation myocardial infarction
【24h】

Comparison of outcomes for patients ≥75 years of age treated with pre-hospital reduced-dose fibrinolysis followed by percutaneous coronary intervention versus percutaneous coronary intervention alone for treatment of st-elevation myocardial infarction

机译：院前降剂量纤溶治疗并经皮冠状动脉介入治疗与单独经皮冠状动脉介入治疗竖部心肌梗死≥75岁患者的结局比较

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A coordinated system of care for patients with ST-segment elevation myocardial infarctions that includes prehospital administration of reduced-dose fibrinolytic agents coupled with urgent percutaneous coronary intervention (PCI), termed FAST-PCI, has been shown to be at least as effective as primary PCI (PPCI) alone. However, this reduced-dose fibrinolytic strategy could be associated with increased bleeding risk, especially in elderly patients. The purpose of this study was to examine 30-day outcomes in patients aged ≥75 years with ST-segment elevation myocardial infarctions treated with either strategy. Data from 120 patients aged ≥75 years treated with FAST-PCI were compared with those of 94 patients aged ≥75 years treated with PPCI. The primary comparator was mortality at 30 days. Stroke, reinfarction, and major bleeding were also compared. The groups were well matched for age, cardiac risk factors, and ischemic times. At 30 days, mortality was lower with FAST-PCI than with PPCI (4.2% vs 18.1%, p <0.01). Rates of stroke, reinfarction, and major bleeding (4% vs 2%) were similar in the 2 groups. The FAST-PCI cohort had lower rates of cardiogenic shock on hospital arrival (15% vs 26%, p = 0.05) and completely occluded infarct arteries (Thrombolysis In Myocardial Infarction [TIMI] grade 0 flow, 35% vs 61%, p <0.01). In conclusion, for patients aged ≥75 years with ST-segment elevation myocardial infarctions, a FAST-PCI strategy in a coordinated system of care was associated with reduced 30-day mortality, earlier infarct artery patency, and lower incidence of cardiogenic shock at arrival compared with PPCI, without apparent bleeding, stroke, or reinfarction penalties.
机译：ST段抬高型心肌梗死的协调护理系统，包括院前给予减量纤溶剂和紧急经皮冠状动脉介入治疗（PCI）（称为FAST-PCI），已被证明至少与原发性一样有效。仅PCI（PPCI）。但是，这种减少剂量的纤溶策略可能会增加出血风险，尤其是在老年患者中。这项研究的目的是检查采用上述两种策略治疗的ST段抬高型心肌梗死≥75岁患者的30天预后。将120例≥75岁的FAST-PCI患者与94例≥75岁的PPCI患者进行了比较。主要比较者是30天时的死亡率。还比较了中风，再梗塞和大出血。各组在年龄，心脏危险因素和缺血时间方面均很匹配。在30天时，FAST-PCI的死亡率低于PPCI（4.2％比18.1％，p <0.01）。两组的中风，再梗塞和大出血发生率（4％比2％）相似。 FAST-PCI队列入院时的心源性休克发生率较低（15％比26％，p = 0.05），并且完全阻塞了梗死动脉（心肌梗死血栓溶解[TIMI] 0级血流，35％vs 61％，p < 0.01）。总之，对于年龄≥75岁的ST段抬高型心肌梗死患者，在协调护理系统中采用FAST-PCI策略可降低30天死亡率，更早梗塞动脉通畅以及到达时心源性休克发生率降低与PPCI相比，没有明显的出血，中风或再梗死罚款。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号