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首页> 外文期刊>The American Journal of Cardiology >Usefulness of Low-Density Lipoprotein Cholesterol and Non-High-Density Lipoprotein Cholesterol as Predictors of Cardiovascular Disease in Chinese
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Usefulness of Low-Density Lipoprotein Cholesterol and Non-High-Density Lipoprotein Cholesterol as Predictors of Cardiovascular Disease in Chinese

机译：低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇在中国心血管疾病预测中的作用

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The predictive effect of non high-density lipoprotein cholesterol (non-HDL-C) for cardiovascular disease (CVD) in Chinese general population has not been well demonstrated. The ahn of our study was to examine the relation between non-HDL-C and CVD and compare the predictive effect of non-HDL-C and low-density lipoprotein cholesterol (LDL-C) for CVD in Chinese population. The baseline examination of 27,020 participants aged 35 to 74 years from the China Cardiovascular Health Study and the China Multicenter Collaborative Study of Cardiovascular Epidemiology was conducted in 1998 to 2001. Follow-up evaluation was conducted in 2007 to 2008 with a response rate of 79.8%. Cox proportional hazards regression models were used to obtain the multivariable-adjusted hazard ratios and 95% confidence intervals (CIs) for CVD. Compared with those with non-HDL-C level of <130 mg/dl, multivariable-adjusted hazard ratios of CVD were 1.30 (95% CI 1.04 to 1.62) and 1:93 (95% CI 1.50 to 2.47) in participants with non-HDL-C levels of 160 to 189.9 and >= 190 mg/dl, respectively. An increase of 30 mg/dl in non-HDL-C level would correspond to 15%, 24%, and 12% increase in risk of CVD, coronary heart disease, and stroke, respectively. Using likelihood ratio tests, non-HDL-C appeared to be a similar predictor for CVD incidence as LDL-C (chi-square for non-HDL-C, 18.02, p <0.001; chi-square for LDLC, 18.90, p <0.001). In conclusion, higher non-HDL-C level is associated with the increased CVD incidence and has a similar effect as LDL-C on predicting CVD risk in Chinese. (C) 2015 Elsevier Inc. All rights reserved.
机译：非高密度脂蛋白胆固醇（non-HDL-C）对中国普通人群心血管疾病（CVD）的预测作用尚未得到很好的证明。我们的研究重点是研究非HDL-C与CVD之间的关系，并比较非HDL-C和低密度脂蛋白胆固醇（LDL-C）对中国人群CVD的预测作用。 1998年至2001年对来自中国心血管健康研究和中国心血管流行病学多中心合作研究的27,020名年龄在35至74岁的参与者进行了基线检查。在2007年至2008年进行了随访评估，回应率为79.8％。 。使用Cox比例风险回归模型来获得CVD的多变量调整风险比和95％置信区间（CIs）。与非HDL-C水平<130 mg / dl的那些相比，非HDL-C参与者的CVD的多变量调整危害比为1.30（95％CI 1.04至1.62）和1:93（95％CI 1.50至2.47）。 -HDL-C水平分别为160至189.9和> = 190 mg / dl。非HDL-C水平增加30 mg / dl分别对应于CVD，冠心病和中风的风险增加15％，24％和12％。使用似然比测试，非HDL-C似乎是与LDL-C类似的CVD发生率预测指标（非HDL-C的卡方值为18.02，p <0.001; LDLC的卡方值为18.90，p <0.001 0.001）。总之，较高的非HDL-C水平与CVD发生率增加相关，并且与LDL-C在预测中国人CVD风险方面具有相似的作用。 （C）2015 Elsevier Inc.保留所有权利。

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