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首页> 外文期刊>The American Journal of Cardiology >Comparison of osteoprotegerin to traditional atherosclerotic risk factors and high-sensitivity c-reactive protein for diagnosis of atherosclerosis
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Comparison of osteoprotegerin to traditional atherosclerotic risk factors and high-sensitivity c-reactive protein for diagnosis of atherosclerosis

机译：骨保护素与传统动脉粥样硬化危险因素和高敏C反应蛋白的诊断动脉粥样硬化的比较

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Atherosclerosis is the main cause of cardiovascular disease, but the extent of atherosclerosis in individual patients is difficult to estimate. A biomarker of the atherosclerotic burden would be very valuable. The aim of the present study was to evaluate the association of plasma osteoprotegerin (OPG) to clinical and subclinical atherosclerotic disease in a large community-based, cross-sectional population study. In the Copenhagen City Heart Study, OPG concentrations were measured in 5,863 men and women. A total of 494 participants had been hospitalized for ischemic heart disease or ischemic stroke, and compared to controls, this group with clinical atherosclerosis had higher mean OPG (1,773 vs 1,337 ng/L, p <0.001) and high-sensitivity C-reactive protein (2.3 vs 1.6 mg/L, p <0.001). In a multivariate model with age, gender, body mass index, hypertension, diabetes, hypercholesterolemia, smoking status, estimated glomerular filtration rate, high-sensitivity C-reactive protein, and OPG, OPG remained significantly associated with clinical atherosclerosis (p <0.01); high-sensitivity C-reactive protein, in contrast, did not (p = 0.74). In the control group without clinical atherosclerosis, OPG was independently associated with hypertension, diabetes, hypercholesterolemia, smoking, and subclinical peripheral atherosclerosis as measured by ankle brachial index. For each doubling of the plasma OPG concentration, the risk for subclinical peripheral atherosclerosis increased by 50% (p <0.001) after multivariate adjustment. In conclusion, OPG appears to be a promising biomarker of atherosclerosis that is independently associated with traditional risk factors of atherosclerosis, subclinical peripheral atherosclerosis, and clinical atherosclerotic disease such as ischemic heart disease and ischemic stroke.
机译：动脉粥样硬化是心血管疾病的主要原因，但是个别患者的动脉粥样硬化程度难以估计。动脉粥样硬化负担的生物标志物将非常有价值。本研究的目的是在基于社区的大型横断面研究中评估血浆骨保护素（OPG）与临床和亚临床动脉粥样硬化疾病的相关性。在哥本哈根市心脏研究中，测量了5,863名男性和女性的OPG浓度。共有494名因缺血性心脏病或缺血性中风住院的患者，与对照组相比，该组临床动脉粥样硬化患者的平均OPG较高（1,773 vs 1,337 ng / L，p <0.001）和高敏感性C反应蛋白（2.3 vs 1.6 mg / L，p <0.001）。在具有年龄，性别，体重指数，高血压，糖尿病，高胆固醇血症，吸烟状况，估计的肾小球滤过率，高敏C反应蛋白和OPG的多元模型中，OPG仍与临床动脉粥样硬化显着相关（p <0.01） ;相比之下，高敏感性C反应蛋白则没有（p = 0.74）。在无临床动脉粥样硬化的对照组中，OPG与踝肱指数相关地独立于高血压，糖尿病，高胆固醇血症，吸烟和亚临床性外周动脉粥样硬化。血浆OPG浓度每增加一倍，经过多变量调整后，亚临床外周动脉粥样硬化的风险增加50％（p <0.001）。总之，OPG似乎是一种有前途的动脉粥样硬化生物标志物，与传统的动脉粥样硬化，亚临床性外周动脉粥样硬化和临床动脉粥样硬化疾病（如缺血性心脏病和缺血性中风）的传统危险因素独立相关。

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