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首页> 外文期刊>The American Journal of Cardiology >Relation of ventricular premature complexes to heart failure (from the Atherosclerosis Risk in Communities [ARIC] study)
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Relation of ventricular premature complexes to heart failure (from the Atherosclerosis Risk in Communities [ARIC] study)

机译：室性早搏与心力衰竭的关系（来自社区的动脉粥样硬化风险[ARIC]研究）

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摘要

Analogous to rapid ventricular pacing, frequent ventricular premature complexes (VPCs) can predispose over time to cardiomyopathy and subsequent heart failure (HF). We examined the association of frequent VPCs with HF incidence in a population-based cohort, free of HF and coronary heart disease at baseline. At study baseline (1987 to 1989), <1 VPC on a 2-minute rhythm electrocardiographic strip was seen in 5.5% (739 of 13,486) of the middle-age (45 to 64 years old at baseline) white and black, men and women of the Atherosclerosis Risk In Communities cohort. Incident HF was defined as the first appearance of International Classification of Diseases code 428.x in the hospital discharge record or death certificate through 2005. During an average follow-up of 15.6 years, incident HF was seen in 10% the participants (19.4% of those with VPCs vs 9.4% of those without). The age-, race-, and gender-adjusted hazard ratio of HF for VPCs was 1.89 (95% confidence interval 1.59 to 2.24). After multivariable adjustment for potential confounders, the hazard ratio of HF for those with any VPC versus no VPC was 1.63 (95% confidence interval 1.36 to 1.96). After additional adjustment for incident coronary heart disease as a time-varying covariate, the hazard ratio was 1.71 (95% confidence interval 1.42 to 2.08). Those with a greater frequency of VPCs or complex VPCs had similar rates of HF compared to those with a single VPC and all had rates greater than those with no VPC. In conclusion, in this large population-based cohort, the presence of VPCs was associated with incident HF, independent of incident coronary heart disease.
机译：与快速起搏相似，频繁的室性早搏复合物（VPC）随时间易患心肌病和随后的心力衰竭（HF）。我们在基线人群中无HF和冠心病的人群研究中，检查了频繁VPC与HF发生率的关系。在研究基线（1987年至1989年），年龄为5.5％（基线的45至64岁）的中年（黑人和男性）的5.5％（13,486人中的5.5％）在2分钟的节奏心电图带上看到<1 VPC社区中有动脉粥样硬化风险的女性。 HF的定义是直至2005年在医院出院记录或死亡证明中首次出现国际疾病分类代码428.x。在平均15.6年的随访中，有10％的参与者（19.4％）发现了HF拥有VPC的用户比例为9.4％）。对于VPC，HF的年龄，种族和性别调整后的危险比为1.89（95％置信区间1.59至2.24）。在对潜在混杂因素进行多变量调整后，有任何VPC与无VPC的人相比，HF的危险比为1.63（95％置信区间1.36至1.96）。在针对随时间变化的协变量对突发性冠心病进行额外调整后，危险比为1.71（95％置信区间为1.42至2.08）。 VPC频率较高或复杂VPC频率较高的频率与单VPC频率相似，所有频率均高于无VPC的频率。总之，在这个以人群为基础的大队列中，VPC的存在与HF的发生有关，而与冠心病无关。

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