...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Cardiology >Usefulness of Combining Electrocardiographic and Echocardiographic Findings and Brain Natriuretic Peptide in Early Detection of Cardiac Amyloidosis in Subjects With Transthyretin Gene Mutation
【24h】

Usefulness of Combining Electrocardiographic and Echocardiographic Findings and Brain Natriuretic Peptide in Early Detection of Cardiac Amyloidosis in Subjects With Transthyretin Gene Mutation

机译：结合心电图和超声心动图检查结果和脑钠尿肽对甲状腺素转运蛋白基因突变患者心脏淀粉样变性的早期检测

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Early noninvasive identification of cardiac amyloidosis (CA) is of growing clinical importance. Low voltage on electrocardiogram (ECG), increased left ventricular (LV) septal thickness (ST), and global longitudinal strain (GLS) on echocardiography, and elevated brain natriuretic peptides (BNP) are used as surrogates of CA. Thirty-five patients (50 +/- 14 years, 22 women) underwent electrocardiography to analyze low-voltage QRS (<15 mV) pathologic Q waves, poor R-wave progression, ST-T abnormalities, and left bundle branch block. An ECG was considered abnormal if at least one ECG alteration was present. Echocardiography was used to analyze LVST, E/E', and GLS. All participants also had BNP blood testing. Tc-99m-3,3-diphosphono-1,2 propanodicarboxylic acid scintigraphy assumed as a reference method showed CA in 18 patients (51%, CA group) and no accumulation in 17 patients (no CA group). In descending order of accuracy, LVST >14 mm, E/E' >6.6, GLS <14.1, BNP >129 pg/ml, and an overall abnormal ECG showed good capability to distinguish patients with and without CA. All these parameters were predictors of CA in univariate analysis, whereas low-voltage QRS showed the worst performance. LVST >14 mm (p = 0.002) was the best independent predictor of CA, achieving sensitivity of 78% and accuracy of 89%. However, an LVST >14 mm (p = 0.005) plus an abnormal ECG (p = 0.03) show together a greater sensitivity, equal to 89%, in identifying CA. An integrated evaluation of ECG and echocardiography is a sensitive and low-cost technical approach to identify CA in patients with transthyretin gene mutation. (C) 2015 Elsevier Inc. All rights reserved.
机译：早期对淀粉样变性病（CA）进行非侵入式识别的临床重要性日益提高。心电图上的低电压（ECG），左心室（LV）间隔厚度增加（ST）和超声心动图上的整体纵向应变（GLS）以及升高的脑钠肽（BNP）被用作CA的替代物。 35例患者（50 +/- 14岁，22名女性）接受了心电图检查，以分析低压QRS（<15 mV）病理Q波，R波进展不良，ST-T异常和左束支传导阻滞。如果至少存在一次ECG改变，则认为ECG异常。超声心动图用于分析LVST，E / E'和GLS。所有参与者还进行了BNP血液测试。假定作为参考方法的Tc-99m-3,3-二膦酰基1,2-丙二羧酸闪烁显像显示18例患者（51％，CA组）出现CA，17例患者（无CA组）未出现累积。按照准确度从高到低的顺序，LVST> 14 mm，E / E'> 6.6，GLS <14.1，BNP> 129 pg / ml，总体心电图异常表现出良好的区分有无CA患者的能力。所有这些参数都是单变量分析中CA的预测指标，而低压QRS表现最差。 LVST> 14 mm（p = 0.002）是CA的最佳独立预测指标，灵敏度为78％，准确度为89％。但是，LVST> 14 mm（p = 0.005）加上异常的ECG（p = 0.03）时，在识别CA方面显示出更高的灵敏度，等于89％。心电图和超声心动图的综合评估是一种灵敏且低成本的技术方法，可识别转甲状腺素蛋白基因突变患者的CA。 （C）2015 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号