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首页> 外文期刊>The American Journal of Cardiology >Age-Related Effects of Smoking on Coronary Artery Disease Assessed by Gray Scale and Virtual Histology Intravasculat Ultrasound
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Age-Related Effects of Smoking on Coronary Artery Disease Assessed by Gray Scale and Virtual Histology Intravasculat Ultrasound

机译：灰度和虚拟组织学血管内超声评估吸烟对冠状动脉疾病的年龄相关影响

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Although smoking is a risk factor for coronary atherosclerosis, the age-related impact on lesion morphology has not been studied. The aim of this study was to assess the age-related impact of smoking on the extent of atherosclerosis and arterial remodeling. In Providing Regional Observations to Study Predictors of Events in the Coronary Tree, 687 patients with acute coronary syndrome underwent 3-vessel gray scale and virtual histology intravascular ultrasound imaging of 3,185 nonculprit lesions. In 207 patients 565 years, current (smoking within 1 month) and former (no smoking for >1 month) smokers showed significantly smaller normalized volumes of external elastic membrane (EEM), lumen, and P + M (plaque + media) compared with nonsmokers. At the minimal lumen area site, current and former smokers had significantly smaller EEM, lumen, and P + M areas than nonsmokers. Conversely, in 480 patients >65 years, current smokers had greater normalized P + M volumes than nonsmokers with no difference in normalized EEM or lumen volumes. Finally, in patients >65 years (but not in patients 565 years), current smokers showed more plaque ruptures (4.7% vs 1.8%, p = 0.05) and echolucent plaques (8.3% vs 3.9%, p = 0.05) compared with nonsmokers. On multivariable analysis, a history of smoking (combining current and former smoking) predicted smaller normalized EEM volumes compared with nonsmokers 565 years. In conclusion, in patients 565 years, but not in patients >65 years, smoking had a vascular constrictive effect that contributed to severe luminal stenosis. Conversely, smokers >65 years had more plaque with greater plaque instability. (C) 2015 Elsevier Inc. All rights reserved.
机译：尽管吸烟是冠状动脉粥样硬化的危险因素，但尚未研究年龄对病变形态的影响。这项研究的目的是评估吸烟对动脉粥样硬化和动脉重构程度的年龄相关影响。在为研究冠状动脉事件的预测因素提供区域观察的过程中，对687例急性冠状动脉综合征患者进行了3血管灰度和3185个非罪犯病变的虚拟组织学血管内超声成像。在565年的207位患者中，当前（1个月内吸烟）和以前（1个月内不吸烟）吸烟者的外弹性膜（EEM），内腔和P + M（斑块+介质）的标准化体积明显小于不吸烟者。在最小管腔区域，与不吸烟者相比，目前和以前的吸烟者的EEM，管腔和P + M区域明显较小。相反，在480名65岁以上的患者中，当前吸烟者的正常P + M量比不吸烟者大，而正常EEM或管腔容量无差异。最后，与不吸烟者相比，> 65岁的患者（而不是565岁的患者没有），目前的吸烟者显示出更多的斑块破裂（4.7％比1.8％，p = 0.05）和回声斑块（8.3％比3.9％，p = 0.05）。 。在多变量分析中，与不吸烟者565年相比，吸烟史（结合当前和以前的吸烟）预测的标准化EEM量较小。总之，在565岁的患者中，而不是在65岁以上的患者中，吸烟没有血管收缩作用，导致严重的管腔狭窄。相反，> 65岁的吸烟者有更多的斑块，斑块不稳定。 （C）2015 Elsevier Inc.保留所有权利。

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