Exercise Heart Rates in Patients With Hypertrophic Cardiomyopathy

Luo Hong-Chang; Dimaano Veronica L.; Kembro Jackelyn M.; Hilser Alex; Hurtado-de-Mendoza David; Pozios Iraklis; Tomas Miguel S.; Yalcin Hulya; Dolores-Cerna Ketty; Mormontoy Wilfredo; Aon Miguel A.; Cameron Duke; Bluemke David A.; Stewart Kerry J.; Russell Stuart D.; Cordova Jorge G.; Abraham Theodore P.; Abraham M. Roselle

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Exercise Heart Rates in Patients With Hypertrophic Cardiomyopathy

机译：肥厚性心肌病患者的运动心率

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The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC. (C) 2015 Elsevier Inc. All rights reserved.

机译：研究了肥厚型心肌病（HC）患者的运动心率（HR）曲线及其与心功能和心律不齐的关系。在273例HC患者和95个年龄匹配的健康对照者的跑步机运动测试期间和之后，计算了慢性反应（CR）和心率恢复（HRR）。与对照组相比，HC患者的变时性无行为能力患病率更高，HRR1-5min更低。运动能力，舒张功能（由E / e'评估）和左心房容积指数与HC中的HRR1min和CR相关。间隔肌切除术与变时功能不全的减少有关，但不影响HRR1min。总之，CR和HRR1min受损与晚期疾病有关，并且似乎不是表明HC高危状态的独立临床标志物。通过滴定消极变时性药物剂量，肌瘤切除术和心房起搏来改善CR，可能有助于增加HC患者的运动能力。（C）2015 Elsevier Inc.保留所有权利。

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《The American Journal of Cardiology》 |2015年第8期|共7页
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Luo Hong-Chang; Dimaano Veronica L.; Kembro Jackelyn M.; Hilser Alex; Hurtado-de-Mendoza David; Pozios Iraklis; Tomas Miguel S.; Yalcin Hulya; Dolores-Cerna Ketty; Mormontoy Wilfredo; Aon Miguel A.; Cameron Duke; Bluemke David A.; Stewart Kerry J.; Russell Stuart D.; Cordova Jorge G.; Abraham Theodore P.; Abraham M. Roselle;
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中图分类心脏、血管（循环系）疾病;
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1. Exercise Heart Rates in Patients With Hypertrophic Cardiomyopathy [J] . Luo Hong-Chang, Dimaano Veronica L., Kembro Jackelyn M., The American Journal of Cardiology . 2015,第8期

机译：肥厚性心肌病患者的运动心率
2. Big heart, no longer a big problem: using catecholamine‐based quantifications may be an effective means to prescribe exercise to non‐obstructive hypertrophic cardiomyopathy patients [J] . Spector Steven, Debi Ryan, Shin Jin The Journal of Physiology . 2019,第9期

机译：大心脏，不再是一个大问题：使用基于儿茶酚胺的量化可能是对非阻塞性肥厚性心肌病患者进行锻炼的有效手段
3. Exercise and heart disease: From athletes and arrhythmias to hypertrophic cardiomyopathy and congenital heart disease [J] . ZaidiA., SharmaS. Future cardiology . 2013,第1期

机译：运动和心脏病：从运动员和心律失常到肥厚型心肌病和先天性心脏病
4. Dynamic analysis of the correlation integral of Heart Rate Variability in hypertrophic cardiomyopathy patients [C] . Carvajal, R., Vallverdu, Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE . 2001

机译：肥厚型心肌病患者心率变异性相关积分的动态分析
5. Turbulent simulations of feline aortic flow under hypertrophic cardiomyopathy heart condition. [D] . Borse, Manish Rajendra. 2016

机译：肥厚型心肌病心脏条件下猫主动脉血流的湍流模拟。
6. Exercise Heart Rates in Patients with Hypertrophic Cardiomyopathy [O] . Hong-Chang Luo, Veronica Lea Dimaano, Jackelyn M. Kembro, -1

机译：肥厚性心肌病患者的运动心率
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8. Dynamic Analysis of the Correlation Integral of Heart Rate Variability in Hypertrophic Cardiomyopathy Patients. [R] . Carvajal, R., Vallverdu, M., Zebrowski, J. J., 2001

机译：肥厚型心肌病患者心率变异相关积分的动态分析。

Exercise Heart Rates in Patients With Hypertrophic Cardiomyopathy

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