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首页> 外文期刊>The American Journal of Cardiology >Prognostic value of uric acid in patients with ST-elevated myocardial infarction undergoing primary coronary intervention
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Prognostic value of uric acid in patients with ST-elevated myocardial infarction undergoing primary coronary intervention

机译：尿酸在ST段抬高型心肌梗死接受冠脉介入治疗中的预后价值

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摘要

Elevated uric acid (UA) levels have been associated with cardiovascular disease in epidemiologic studies. The relation between UA levels and long-term outcomes in patients with ST-segment elevation myocardial infarction who undergo primary percutaneous coronary intervention is not known. Data from 2,249 consecutive patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention were evaluated. Patients were divided into 2 groups with high or low UA using upper limits of normal of 6 mg/dl for women and 7 mg/dl for men. There were 1,643 patients in the low-UA group (mean age 55.9 ± 11.6 years, 85% men) and 606 patients in the high-UA group (mean age 60.5 ± 12.6 years, 76% men). Serum UA levels were 8.0 ± 1.5 mg/dl in the high-UA group and 5.2 ± 1.0 mg/dl in the low-UA group (p <0.001). The in-hospital mortality rate was significantly higher in patients with high UA levels (9% vs 2%, p <0.001), as was the rate of adverse outcomes in patients with high UA. The mean follow-up time was 24.3 months. Cardiovascular mortality, reinfarction, target vessel revascularization, heart failure, and major adverse cardiac events were all significantly higher in the high-UA group. In a multivariate analyses, high plasma UA levels were an independent predictor of major adverse cardiac events in the hospital (odds ratio 2.03, 95% confidence interval 1.25 to 3.75, p = 0.006) and during long-term follow-up (odds ratio 1.64, 95% confidence interval 1.05 to 2.56, p = 0.03). In conclusion, high UA levels on admission are independently associated with in-hospital and long-term adverse outcomes in patients with ST-segment elevation myocardial infarction who undergo primary percutaneous coronary intervention.
机译：在流行病学研究中，尿酸（UA）水平升高与心血管疾病有关。 ST段抬高型心肌梗死患者经原发性经皮冠状动脉介入治疗后，UA水平与长期预后之间的关系尚不清楚。评估了来自2249例连续ST段抬高型心肌梗死患者的资料，这些患者接受了原发性经皮冠状动脉介入治疗。将患者分为UA高或低的2组，女性的正常上限为6 mg / dl，男性的正常上限为7 mg / dl。低UA组有1643例患者（平均年龄55.9±11.6岁，男性占85％），高UA组有606例患者（平均年龄60.5±12.6岁，男性占76％）。高UA组的血清UA水平为8.0±1.5 mg / dl，低UA组的为5.2±1.0 mg / dl（p <0.001）。高UA水平患者的院内死亡率显着更高（9％vs 2％，p <0.001），高UA水平患者的不良结局发生率也较高。平均随访时间为24.3个月。高UA组的心血管死亡率，再梗死，靶血管血运重建，心力衰竭和主要不良心脏事件均显着较高。在多变量分析中，高血浆UA水平是医院主要不良心脏事件（赔率比2.03，95％置信区间1.25至3.75，p = 0.006）和长期随访期间（赔率比1.64）的独立预测因子。 ，95％置信区间1.05至2.56，p = 0.03）。总之，接受STA抬高型心肌梗死并接受经皮冠状动脉介入治疗的患者，入院时UA水平高与院内和长期不良结局独立相关。

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