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首页> 外文期刊>The American journal of drug and alcohol abuse >Family history of alcoholism does not influence adrenocortical hyporesponsiveness in abstinent alcohol-dependent men.
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Family history of alcoholism does not influence adrenocortical hyporesponsiveness in abstinent alcohol-dependent men.

机译：酒精中毒的家族病史不会影响戒酒依赖男性的肾上腺皮质反应不足。

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BACKGROUND: Early abstinence in alcohol-dependent subjects is marked by adrenocortical hyporesponsivity. However, it is uncertain whether the blunted response is primarily attributable to a genetic vulnerability or to the chronic abuse of alcohol. In the present study, the authors investigated the influence of a family history (FH) of alcoholism upon suppressed glucocorticoid reactivity. METHODS: Twenty-two abstinent alcohol-dependent and 14 control men were studied. The cortisol response was assessed in 11 patients following oCRH infusion (.4 ug/kg) and in a separate group of 11 patients following cosyntropin infusion (.01 ug/kg) preceded by high-dose intravenous dexamethasone (8 mg). FH, as determined by self-report, was assessed using two different methods: history of parental alcoholism and number of alcohol-dependent first- and second-degree relatives. RESULTS: Neither a parental history or familial loading of alcoholism had a significant effect upon glucocorticoid responsivity in abstinent alcohol-dependent men. CONCLUSIONS: Adrenocorticol responsiveness in recently abstinent alcohol-dependent men does not appear to reflect a preexisting biologic vulnerability to alcoholism.
机译：背景：酒精依赖型受试者的早期禁欲以肾上腺皮质反应低下为特征。但是，尚不确定钝反应是否主要归因于遗传易感性或长期滥用酒精。在本研究中，作者调查了酒精中毒的家族史（FH）对糖皮质激素反应性抑制的影响。方法：研究了22名戒酒依赖者和14名对照者。在oCRH输注（.4 ug / kg）后评估了11例患者的皮质醇反应，在高剂量静脉注射地塞米松（8 mg）进行了联合促肾上腺皮质激素输注（.01 ug / kg）之后，对另一组11例患者进行了皮质醇反应评估。通过自我报告确定的FH使用两种不同的方法进行评估：父母酗酒史和酒精依赖的一级和二级亲属的数量。结果：酒精中毒的父母的既往史或家族性酗酒对糖皮质激素的反应性均无显着影响。结论：在最近戒酒的酒精依赖型男性中，肾上腺皮质激素的反应性似乎并未反映出先前对酒精中毒的生物学脆弱性。

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