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首页> 外文期刊>The journal of physiological sciences: JPS >Cough reflex is additively potentiated by inputs from the laryngeal and tracheobronchial (corrected) receptors and enhanced by stimulation of the central respiratory neurons.
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Cough reflex is additively potentiated by inputs from the laryngeal and tracheobronchial (corrected) receptors and enhanced by stimulation of the central respiratory neurons.

机译：喉反射和气管支气管（校正）受体的输入可加重咳嗽反射，刺激中央呼吸神经元可增强咳嗽反射。

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摘要

The cough is an essential airway defense reflex. In this study we investigated the coordination of inputs from the laryngeal and tracheobronchial receptors in the cough reflex. In 15 beagle dogs (7-9 kg) lightly anesthetized with intravenous profobol (20-30 mg/kg/h), the cough response was elicited with mechanical stimulation of either the vocal chord or tracheal bifurcation. Simultaneous stimulation of both sites increased all the parameters of cough strength, that is, mean pleural pressure (P (pl)), mean expiratory flow, number of cough bouts, and cough duration, in comparison with stimulation of the sites individually. The increases in mean P (pl) and cough duration reached statistical significance (13.3 vs. 18.4 cmH(2)O and 13.3 vs. 18.2 s, respectively). When the anesthetic level became deeper, the prolongation of cough duration almost disappeared, but the augmentation of mean P (pl) was much less affected. During stimulation of the central respiratory neurons by intravenous dimorphoramine or acute hyperoxic hypercapnia, the cough strength increased significantly. We concluded that inputs from the laryngeal and tracheobonchial cough receptors acted in concert and potentiated the cough reflex. Furthermore, stimulation of the central respiratory neurons may increase the intensity of a cough response.
机译：咳嗽是必不可少的呼吸道防御反射。在这项研究中，我们调查了咳嗽反射中喉和气管支气管受体输入的协调性。在15只比格犬（7-9公斤）中，静脉内使用前药（20-30毫克/公斤/小时）麻醉，通过机械刺激声带或气管分叉引起咳嗽反应。与单独刺激部位相比，同时刺激两个部位增加了所有咳嗽强度参数，即平均胸膜压（P（pl）），平均呼气流量，咳嗽发作次数和咳嗽持续时间。平均P（pl）和咳嗽持续时间的增加达到统计学显着性（分别为13.3 vs. 18.4 cmH（2）O和13.3 vs. 18.2 s）。当麻醉剂的水平变深时，咳嗽持续时间的延长几乎消失了，但是平均P（pl）的增加受到的影响却小得多。在静脉注射二吗啡胺或急性高氧高碳酸血症刺激中枢呼吸神经元期间，咳嗽强度显着增加。我们得出的结论是，喉和气管支气管咳嗽受体的输入共同起作用并增强了咳嗽反射。此外，刺激中央呼吸神经元可增加咳嗽反应的强度。

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