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首页> 外文期刊>The Journal of Physiology >Coupling and uncoupling of activity-dependent increases of neuronal activity and blood flow in rat somatosensory cortex.
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Coupling and uncoupling of activity-dependent increases of neuronal activity and blood flow in rat somatosensory cortex.

机译：大鼠体感皮层中神经活动和血流量的活动依赖性增加的偶联和解偶联。

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1. Electrical stimulation of the infraorbital nerve was used to examine the coupling between neuronal activity and cerebral blood flow (CBF) in rat somatosensory cortex by laser Doppler flowmetry and extracellular recordings of field potentials. 2. The relationship between field potential (FP) and CBF amplitudes was examined as a function of the stimulus intensity (0--2.0 mA) at fixed frequency (3 Hz). FP amplitudes up to 2.0-2.5 mV were unaccompanied by increases of CBF. Above this threshold, CBF and FP amplitudes increased proportionally. 3. At fixed stimulus intensity of 1.5 mA, CBF increases were highly correlated to FP amplitudes at low frequencies of stimulation (< 2 Hz), but uncoupling was observed at stimulation frequencies of 2--5 Hz. The evoked responses were independent of stimulus duration (8--32 s). 4. The first rise in CBF occurred within the first 0.2 s after onset of stimulation in the upper 0--250 microm of the cortex. Latencies were longer (1.0--1.2 s) in lower cortical layers in which CBF and FP amplitudes were larger. 5. Local AMPA receptor blockade attenuated CBF and FP amplitudes proportionally. 6. This study showed that activity-dependent increases in neuronal activity and CBF were linearly coupled under defined conditions, but neuronal activity was well developed before CBF started to increase. Consequently, the absence of a rise in CBF does not exclude the presence of significant neuronal activity. The CBF increase in upper cortical layers preceded the rise in lower layers suggesting that vessels close to or at the brain surface are the first to react to neuronal activity. The activity-dependent rise in CBF was explained by postsynaptic activity in glutamatergic neurons.
机译：1.用激光刺激眶下神经通过激光多普勒血流仪和场电位的细胞外记录来检查大鼠体感皮层神经元活动与脑血流（CBF）之间的耦合。 2.根据固定频率（3 Hz）下刺激强度（0--2.0 mA）的函数，研究了场势（FP）和CBF幅度之间的关系。 FP振幅高达2.0-2.5 mV不伴随CBF的增加。高于此阈值，CBF和FP振幅成比例增加。 3.在固定的1.5 mA刺激强度下，低频刺激（<2 Hz）时CBF的增加与FP振幅高度相关，但在2--5 Hz刺激频率下观察到解耦。诱发的反应与刺激持续时间（8--32 s）无关。 4. CBF的首次升高发生在刺激开始后的头0.2 s内，位于皮层的上方0--250微米。在CBF和FP振幅较大的较低皮质层中，潜伏期较长（1.0--1.2 s）。 5.局部AMPA受体阻滞成比例地减弱了CBF和FP振幅。 6.这项研究表明，在特定条件下，神经元活动和CBF的活动依赖性增加呈线性耦合，但在CBF开始增加之前，神经元活动发育良好。因此，不存在CBF升高并不排除存在明显的神经元活动。大脑皮层的CBF升高先于皮质的下层升高，这表明靠近或位于大脑表面的血管是第一个对神经元活动做出反应的血管。谷氨酸能神经元的突触后活性解释了CBF的活性依赖性升高。

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