Characterization and Genetic Study of the Ovine alpha_(S2)-Casein (CSN1S2) Allele B

G. Picariello; D. Rignanese; S. Chessa

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Characterization and Genetic Study of the Ovine alpha_(S2)-Casein (CSN1S2) Allele B

机译：绵羊α_（S2）-酪蛋白（CSN1S2）等位基因B的表征与遗传研究

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An interesting and quite complex protein pattern has been described at ovine milk proteins but the genetic control of the variation observed was assessed only in few cases. The aim of this work was to characterize the ovine alpha_(S2)-casein (CSN1S2) B variant, first observed in the Italian Gentile di Puglia, a fine-wooled ovine breed, and to investigate its occurrence in two further breeds, the Sarda and Camosciata, which are the most widespread dairy breeds in Italy. The B variant differs from the most common form A with two amino acid exchanges: Asp_(75) -> Tyr_(75) and Ile_(105) -> Val_(105). The first substitution, resulting in a loss of a negative charge, is responsible for the higher isoelectric point of the B protein variant, which allows its detection by isoelectric focusing electrophoresis (IEF). The occurrence of CSN1S2*B in Sarda and Comisana was demonstrated. Since the Asp_(75) -> Tyr_(75) substitution modifies the protein electric charge, milk properties may result affected to some extent.

机译：在羊乳蛋白上描述了一种有趣且非常复杂的蛋白模式，但仅在少数情况下评估了观察到的变异的遗传控制。这项工作的目的是鉴定绵羊alpha_（S2）-酪蛋白（CSN1S2）B变种的特征，该变种首先在细毛的意大利品种Gentile di Puglia中观察到，并研究其在另外两个变种Sarda中的存在和Camosciata，它们是意大利分布最广泛的乳制品品种。 B变体不同于最常见的形式A，具有两个氨基酸交换：Asp_（75）→Tyr_（75）和Ile_（105）→Val_（105）。第一次取代导致负电荷的损失，是B蛋白变异体较高的等电点的原因，它可以通过等电聚焦电泳（IEF）进行检测。证明了在Sarda和Comisana中发生了CSN1S2 * B。由于Asp_（75）-> Tyr_（75）取代会改变蛋白质电荷，因此牛奶性能可能会受到一定程度的影响。

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《The protein journal》 |2009年第8期|共8页
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G. Picariello; D. Rignanese; S. Chessa;
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1. Characterization and Genetic Study of the Ovine alpha_(S2)-Casein (CSN1S2) Allele B [J] . G. Picariello, D. Rignanese, S. Chessa The protein journal . 2009,第7a8期

机译：绵羊α_（S2）-酪蛋白（CSN1S2）等位基因B的表征与遗传研究
2. Genetic polymorphism of goat alpha(S2)-casein (CSN1S2) and evidence for a further allele [J] . Erhardt G, Jager S, Budelli E, Milchwissenschaft . 2002,第3期

机译：山羊α（S2）-酪蛋白（CSN1S2）的遗传多态性和进一步的等位基因的证据
3. Single nucleotide polymorphisms in the ovine CSN1S2 gene for alpha _S2-casein. [J] . Padilla J. A., Corral J. M., Quesada A., Spanish Journal of Agricultural Research . 2013,第1期

机译：绵羊CSN1S2基因中α_{S2 -酪蛋白的单核苷酸多态性。}
4. κ-Carrageenan Interaction with Bovine and Caprine Caseins as Shown by Sedimentation and NMR Spectroscopic Techniques Implication of Surface Charge by a Homologous Three-Dimensional Model for α_(S2)-Casein: κ-Carrageenan-Casein Interaction [C] . Harold M. Farrell Jr., Adela Mora-Gutierrez American Chemical Society . 2006

机译：κ-甲甲苯烷蛋白与牛和葫芦酪蛋白的相互作用，如沉淀和NMR光谱技术所示，通过同源三维模型对α_（S2）的含义 - 酪蛋白：κ-角叉菜蜡酪蛋白相互作用
5. From phenotype to protein folding: Characterization of the allele-dependent genetic interactions between chaperonin and co-chaperonin alleles. [D] . Shewmaker, Frank Paul. 2003

机译：从表型到蛋白质折叠：伴侣蛋白和伴侣蛋白等位基因之间等位基因依赖性遗传相互作用的表征。
6. Characterization of mare caseins. Identification of $\alpha_{{\bf S1}}$- and $\alpha_{{\bf S2}}$- caseins [O] . Ochirkhuyag, Baldorj, Chobert, Jean-Marc, Dalgalarrondo, Michèle, 2000

机译：母马酪蛋白的表征。鉴定$ \ alpha _ {{\ bf S1}} $-和$ \ alpha _ {{\ bf S2}} $-酪蛋白

Characterization and Genetic Study of the Ovine alpha_(S2)-Casein (CSN1S2) Allele B

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