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首页> 外文期刊>The Quarterly journal of experimental psychology, B. Comparative and physiological psychology >Contrasting hippocampal and perirhinal cortex function using immediate early gene imaging
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Contrasting hippocampal and perirhinal cortex function using immediate early gene imaging

机译：立即早期基因成像对比海马和周围神经皮层功能

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The perirhinal cortex and hippocampus have close anatomical links, and it might, therefore, be predicted that they have close, interlinked roles in memory. Lesion studies have, however, often failed to support this prediction, providing dissociations and double dissociations between the two regions on tests of object recognition and spatial memory. In a series of rat studies we have compared these two regions using the expression of the immediate early gene c-fos as a marker of neuronal activity. This gene imaging approach makes it possible to assess the relative involvement of different brain regions and avoids many of the limitations of the lesion approach. A very consistent pattern of results was found as the various hippocampal subfields but not the perirhinal cortex show increased c-fos activity following tests of spatial learning. In contrast, the perirhinal cortex but none of the hippocampal subfields show increased c-fos activity when presented with novel rather than familiar visual objects. When novel scenes are created by the spatial rearrangement of familiar objects it is the hippocampus and not the perirhinal cortex that shows c-fos changes. This double dissociation for gene expression accords with that found from lesion studies and highlights the different contributions of the perirhinal cortex and hippocampus to memory.
机译：周围神经皮层和海马具有紧密的解剖联系，因此，可以预测它们在记忆中具有紧密的，相互联系的作用。然而，病变研究常常未能支持这一预测，而是在物体识别和空间记忆测试中提供了两个区域之间的分离和双重分离。在一系列大鼠研究中，我们使用立即早期基因c-fos的表达作为神经元活性的标记，比较了这两个区域。这种基因成像方法使评估不同大脑区域的相对受累成为可能，并且避免了病变方法的许多局限性。发现了非常一致的结果模式，因为在进行空间学习测试后，各种海马亚区却没有周围神经皮层显示出增加的c-fos活性。相反，当呈现新颖而不是熟悉的视觉对象时，周围神经皮质却没有海马亚区显示出增加的c-fos活性。当通过熟悉的对象的空间重排创建新颖的场景时，显示c-fos变化的是海马而不是周围的皮质。基因表达的这种双重解离与病变研究中发现的解离一致，并突出了周围神经皮层和海马对记忆的不同贡献。

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