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首页> 外文期刊>The Journal of Experimental Biology >Characterization of very-low density lipoprotein particle diameter dynamics in relation to egg production in a passerine bird
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Characterization of very-low density lipoprotein particle diameter dynamics in relation to egg production in a passerine bird

机译：雀形鸟中极低密度脂蛋白粒径动态与产蛋量的关系

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摘要

During avian egg production, oestrogen mediates marked increases in hepatic lipid production and changes in the diameter of assembled very-low density lipoprotein (VLDL). A nearly complete shift from generic VLDL (similar to 70 nm in diameter), which transports lipids to peripheral tissues, to yolk-targeted VLDL (VLDLy) (similar to 30 nm), which supplies the yolk with energy-rich lipid, has been observed in the plasma of laying domestic fowl. We validated an established dynamic laser scattering technique for a passerine songbird Taeniopygia guttata, the zebra finch, to characterize the dynamics of VLDL particle diameter distribution in relation to egg production. We predicted that non-gallinaceous avian species that have not been selected for maximum egg production would exhibit less dramatic shifts in lipid metabolism during egg production. As predicted, there was considerable overlap between the VLDL particle diameter distributions of laying and nonlaying zebra finches. But unexpectedly, non-laying zebra finches had VLDL diameter distributions that peaked at small particles and had relatively few large VLDL particles. As a result, laying zebra finches, in comparison, had diameter distributions that were shifted towards larger VLDL particles. Nevertheless, laying zebra finches, like laying chickens, had larger proportions of particles within proposed VLDLy particle diameter ranges than non-laying zebra finches (e.g. sVLDLy: 50% vs 37%). Furthermore, zebra finches and chickens had similar modal (29.7 nm in both species) and median (32.7 nm vs 29.6 nm) VLDL particle diameters during egg production. Therefore, although zebra finches and chickens exhibited opposing directional shifts in VLDL particle diameter distribution during egg production, the modifications to VLDL particle structure in both species resulted in the realization of a common goal, i.e. to produce and maintain a large proportion of small VLDL particles of specific diameters that are capable of being incorporated into newly forming egg yolks.
机译：在禽卵生产过程中，雌激素介导肝脂质生产的显着增加以及组装的极低密度脂蛋白（VLDL）直径的变化。从将脂质转运到周围组织的普通VLDL（直径约70 nm）到以蛋黄为目标的VLDL（VLDLy）（约30 nm）几乎已经完全转变，后者为卵黄提供了能量丰富的脂质。在产家禽的血浆中观察到。我们验证了一种建立的动态激光散射技术，用于对雀斑Taeniopygia guttata（斑雀雀）进行动态表征，以表征VLDL粒径分布与产蛋量有关的动力学。我们预测未选择最大产卵量的非含胆禽类在产卵过程中脂类代谢表现出较少的剧烈变化。如所预测的，斑马雀和非斑马雀的VLDL粒径分布之间存在相当大的重叠。但出乎意料的是，非铺设斑马雀科的VLDL直径分布在小颗粒处达到峰值，而大VLDL颗粒则相对较少。结果，相比之下，铺设斑马雀的直径分布朝较大的VLDL颗粒移动。尽管如此，与建议的VLVLy颗粒直径范围相比，与建议的VLDLy颗粒直径范围相比，与建议的VLDLy颗粒直径范围相比，放置斑马雀的颗粒比例更大（例如sVLDLy：50％对37％）。此外，斑马雀和鸡在产蛋过程中具有相似的模态（两种物种均为29.7 nm）和中值（32.7 nm对29.6 nm）VLDL粒径。因此，尽管斑马雀和鸡在产蛋过程中显示出相反的VLDL粒径分布方向变化，但两种物种对VLDL颗粒结构的改变仍实现了一个共同的目标，即生产和维持较大比例的小VLDL颗粒能够结合到新形成的蛋黄中的特定直径

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