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首页> 外文期刊>The Journal of Experimental Biology >IONIC COMPOSITION OF ENDOLYMPH IN TELEOSTS - ORIGIN AND IMPORTANCE OF ENDOLYMPH ALKALINITY
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IONIC COMPOSITION OF ENDOLYMPH IN TELEOSTS - ORIGIN AND IMPORTANCE OF ENDOLYMPH ALKALINITY

机译：硬骨鱼中内毒素的离子组成-内生碱的重要性。

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摘要

Ionic (Na+, K+, Cl-, PO43-, pH), total CO2, total calcium and protein concentrations in the plasma and endolymph of the inner ear were compared in trout Oncorhynchus mykiss and turbot Scophthalmus maximus. In both species, saccular endolymph was characterized by high levels of K+ and total CO2 and in trout by an alkaline pH, The kinetic characteristics of proton secretion across the saccular epithelium of trout were investigated using a titration technique in which isolated saccules were mounted as closed sacs. The rate of proton secretion depends strongly on the pH of the Ringer's solution and secretion stops at a pH below 7.2, Proton secretion is driven by an energy-dependent mechanism involving basolateral ouabain-sensitive Na+/K+ exchangers. Proton secretion was partially inhibited by acetazolamide and completely inhibited in Na+-free Ringer or in the presence of 1 mmol l(-1) amiloride. A cellular model stressing the importance of proton exchange through the saccular epithelium is proposed to explain the regulation of endolymph pH, a crucial factor for the deposition of otolith calcium. [References: 19]
机译：比较了鳟鱼Oncorhynchus mykiss和大菱turboScophthalmus maximus的离子（Na +，K +，Cl-，PO43-，pH），总二氧化碳，总钙和蛋白质浓度，以及内耳的内淋巴。在这两个物种中，囊状内淋巴的特征在于高水平的K +和总CO2含量，鳟鱼的碱性pH值高。通过滴定技术研究了鳟鱼囊状上皮细胞质子分泌的动力学特征，其中分离的囊泡封闭放置囊质子分泌的速率在很大程度上取决于林格氏溶液的pH值，并且在pH值低于7.2时停止分泌，质子的分泌是由涉及基底外侧哇巴因敏感性Na + / K +交换子的能量依赖性机制驱动的。乙酰唑胺可部分抑制质子分泌，在无Na +的林格液中或在存在1 mmol l（-1）阿米洛利的情况下，质子分泌会被完全抑制。提出了一个强调通过囊状上皮进行质子交换的重要性的细胞模型来解释内淋巴pH的调节，这是耳石钙沉积的关键因素。 [参考：19]

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