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首页> 外文期刊>The Journal of Experimental Biology >ROLE OF SEROTONIN IN FISH IMMUNOMODULATION
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ROLE OF SEROTONIN IN FISH IMMUNOMODULATION

机译：血清素在鱼类免疫调节中的作用

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In the recent past, the importance of the fish brain monoaminergic system in aggression, mating and feeding has been documented, There are several apparent the functioning of the fish and monoaminergic systems, In fish, the hypermetabolism of catecholamines (norepinephrine and dopamine) and indoleamine (serotonin, 5-hydroxytryptamine, 5-HT) has been found to be associated with stressful conditions, In contrast to the situation in mammals, these monoamines can pass through the blood-brain barrier in teleost fishes, contributing to the high levels of biogenic amines in the periphery, Hence, high levels of serotonin in the peripheral circulation, during different stressful conditions, may influence the functioning of other physiological systems, notably the immune system, Serotonin is also stored in considerable amounts by mast cells and platelets, and can be synthetized by chromaffin cells, In mammals, it has been established that 5-HT modulates immune function at a variety of levels, However, little is known about the role of serotonin in the functioning of the immune system in fish, In this perspective article, we will discuss our results and the findings of other laboratories, although meagre on this subject, on the possible role of serotonin in the functioning of immunocompetent cells in fish. [References: 75]
机译：在最近的历史中，已经证明了鱼脑单胺能系统在侵略，交配和进食中的重要性。鱼和单胺能系统的功能有明显的表现。在鱼中，儿茶酚胺（去甲肾上腺素和多巴胺）和吲哚胺的代谢过度（5-羟色胺，5-羟色胺，5-HT）与压力性疾病有关。与哺乳动物的情况相反，这些单胺可通过硬骨鱼类的血脑屏障，从而导致高水平的生物因此，在不同的压力条件下，外周循环中高水平的5-羟色胺可能会影响其他生理系统的功能，尤其是免疫系统。5-羟色胺还被肥大细胞和血小板大量储存，并且可以由嗜铬细胞合成。在哺乳动物中，已经确定5-HT可以在多种水平上调节免疫功能，迄今为止，关于5-羟色胺在鱼类免疫系统功能中的作用了解甚少。在这篇观点文章中，我们将讨论我们的研究结果和其他实验室的发现，尽管对这一问题的研究还很有限，但是5-羟色胺可能在鱼类中的作用。鱼类中具有免疫能力的细胞的功能。 [参考：75]

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