AMPK ACTIVATOR ACTIVATES HIBERNATOR'S APPETITE

Kathryn Knight

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AMPK ACTIVATOR ACTIVATES HIBERNATOR'S APPETITE

机译：AMPK活化剂激活了解冻剂的食欲

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Some of us may put a few inches on over the course of winter, but not hibernating animals. They gain fat during the late summer ready for fuel when they stop feeding and begin hibernating. But what controls this dramatic switch from gorging to fasting? Gregory Florant from Colorado State University and his colleagues from the University of Arizona – Phoenix, USA, knew that AMP-activated protein kinase (AMPK) acts as an intracellular energy sensor and regulates food intake, so the team decided to test whether it may also play a role in regulating hibernator's eating habits (p. 2031).

机译：我们当中有些人可能会在整个冬天穿上几英寸，但不会让动物冬眠。当他们停止进食并开始冬眠时，它们会在夏末增加脂肪，准备燃料。但是，什么因素控制着这种从食欲到禁食的巨大转变呢？来自科罗拉多州立大学的Gregory Florant和来自美国亚利桑那州凤凰城大学的同事知道，AMP激活的蛋白激酶（AMPK）充当细胞内能量传感器并调节食物摄入量，因此研究小组决定测试它是否也可能在调节冬眠者的饮食习惯中发挥作用（第2031页）。

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《The Journal of Experimental Biology》 |2010年第12期|共2页
作者
Kathryn Knight;
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正文语种 eng
中图分类生物学实验与生物学技术;
关键词
fasting; food intake; hibernation; eating habit; energy sensor;

机译：禁食;食物摄入;冬眠;饮食习惯;能量传感器;

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专利

1. AMPK ACTIVATOR ACTIVATES HIBERNATOR'S APPETITE [J] . Kathryn Knight The Journal of Experimental Biology . 2010,第12期

机译：AMPK活化剂激活了解冻剂的食欲
2. AMPK activation, eEF2 inactivation, and reduced protein synthesis in the cerebral cortex of hibernating chipmunks [J] . Shintaro Yamada, Taito Kamata, Hiroyuki Nawa, Scientific reports. . 2019,第1期

机译：AMPK活化，EEF2灭活，冬眠花栗鼠脑皮层中的蛋白质合成减少
3. Effects of dietary energy level on appetite and central adenosine monophosphate-activated protein kinase (AMPK) in broilers [J] . Hu Xiyi, Wang Yufeng, Sheikhahmadi Ardashir, Journal of Animal Science . 2019,第11期

机译：膳食能量水平对肉鸡食欲和中枢腺苷一磷酸胺激活蛋白激酶（AMPK）的影响
4. Cationic polystyrene nanosphere induces autophagy through inhibition of the Akt/mTOR and activation of the AMPK signaling pathways in macrophage and epithelial cells [C] . Hui-Wen Chiu, Tian Xia, Jui-Chen Tsai, Annual NSTI nanotechnology conference and expo . 2013

机译：阳离子聚苯乙烯纳米球通过抑制Akt / mTOR和激活巨噬细胞和上皮细胞中的AMPK信号通路来诱导自噬
5. Cell contact activates AMP-Activated Protein Kinase (AMPK) through CaMKKbeta and the GTPase Rac1. [D] . Winchester, Trisha. 2017

机译：细胞接触通过CaMKKbeta和GTPase Rac1激活AMP激活的蛋白激酶（AMPK）。
6. AMPK activation eEF2 inactivation and reduced protein synthesis in the cerebral cortex of hibernating chipmunks [O] . Shintaro Yamada, Taito Kamata, Hiroyuki Nawa, -1

机译：冬眠花栗鼠大脑皮层中的AMPK激活eEF2失活和蛋白质合成减少
7. Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation. [O] . Xinbing Sui, Yinghua Xu, Jie Yang, 2014

机译：单独使用二甲双胍与结肠直肠癌细胞的存活结果无关，但ampK活化剂aICaR通过ampK活化使5-氟尿嘧啶的抗癌作用敏感。

AMPK ACTIVATOR ACTIVATES HIBERNATOR'S APPETITE

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