...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Experimental Biology >High or low dietary carbohydrate: protein ratios during first-feeding affect glucose metabolism and intestinal microbiota in juvenile rainbow trout
【24h】

High or low dietary carbohydrate: protein ratios during first-feeding affect glucose metabolism and intestinal microbiota in juvenile rainbow trout

机译：初次喂养期间高或低饮食中碳水化合物：蛋白质的比率会影响幼体虹鳟鱼的葡萄糖代谢和肠道菌群

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Based on the concept of nutritional programming in mammals, we tested whether an acute hyperglucidic-hypoproteic stimulus during first feeding could induce long-term changes in nutrient metabolism in rainbow trout. Trout alevins received during the five first days of exogenous feeding either a hyperglucidic (40% gelatinized starch + 20% glucose) and hypoproteic (20%) diet (VLP diet) or a high-protein (60%) glucose-free diet (HP diet, control). Following a common 105-day period on a commercial diet, both groups were then challenged (65 days) with a carbohydrate-rich diet (28%). Short-and long-term effects of the early stimuli were evaluated in terms of metabolic marker gene expressions and intestinal microbiota as initial gut colonisation is essential for regulating the development of the digestive system. In whole alevins (short term), diet VLP relative to HP rapidly increased gene expressions of glycolytic enzymes, while those involved in gluconeogenesis and amino acid catabolism decreased. However, none of these genes showed persistent molecular adaptation in the liver of challenged juveniles (long term). By contrast, muscle of challenged juveniles subjected previously to the VLP stimulus displayed downregulated expression of markers of glycolysis and glucose transport (not seen in the short term). These fish also had higher plasma glucose (9 h postprandial), suggesting impaired glucose homeostasis induced by the early stimulus. The early stimulus did not modify the expression of the analysed metabolism-related microRNAs, but had short-and long-term effects on intestinal fungi (not bacteria) profiles. In summary, our data show that a short hyperglucidic-hypoproteic stimulus during early life may have a long-term influence on muscle glucose metabolism and intestinal microbiota in trout
机译：基于哺乳动物营养程序设计的概念，我们测试了初次喂养期间急性的高血糖-低蛋白刺激是否可以诱导虹鳟营养代谢的长期变化。在外来喂养的前五天内接受鳟鱼鱼精，即高血糖（40％糊化淀粉+ 20％葡萄糖）和低蛋白（20％）饮食（VLP饮食）或高蛋白（60％）无葡萄糖饮食（HP）饮食，控制）。在通常的105天商业饮食期过后，两组均接受富含碳水化合物的饮食（28％）攻击（65天）。根据代谢标记基因的表达和肠道菌群评估了早期刺激的短期和长期影响，因为最初的肠道定植对于调节消化系统的发育至关重要。在整个alevins（短期）中，相对于HP的饮食VLP迅速增加了糖酵解酶的基因表达，而那些参与糖异生和氨基酸分解代谢的酶则下降了。但是，这些基因均未在受攻击的少年的肝脏中显示出持久的分子适应性（长期）。相比之下，先前受到VLP刺激的受攻击少年的肌肉显示出糖酵解和葡萄糖转运标志物的表达下调（短期内未见）。这些鱼还具有较高的血浆葡萄糖（餐后9小时），表明早期刺激引起的葡萄糖稳态下降。早期刺激并未改变所分析的与代谢相关的微小RNA的表达，但对肠道真菌（而非细菌）的分布具有短期和长期影响。总之，我们的数据表明，在生命的早期，短暂的高血糖-低蛋白刺激可能会对鳟鱼的肌肉葡萄糖代谢和肠道菌群产生长期影响

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号