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首页> 外文期刊>The Journal of foot and ankle surgery: official publication of the American College of Foot and Ankle Surgeons >A prospective study of 20 foot and ankle wounds treated with cryopreserved amniotic membrane and fluid allograft
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A prospective study of 20 foot and ankle wounds treated with cryopreserved amniotic membrane and fluid allograft

机译：冷冻保存羊膜和同种异体移植物治疗20足踝关节伤口的前瞻性研究

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摘要

We reviewed the background information and previous clinical studies that considered the use of allogeneic amniotic tissue and fluid (granulized amniotic membrane and amniotic fluid) in the treatment of chronic diabetic foot wounds. This innovation represents a relatively new approach to wound management by delivering a unique allograft of live human cells in a nonimmunogenic structural tissue matrix. Developed to fill soft tissue defects and bone voids and to convey antimicrobial and anti-inflammatory capabilities, granulized amniotic membrane and amniotic fluid does not require fetal death, because its procurement is performed with maternal consent during birth. In the present investigation, 20 chronic wounds (20 patients) that had been treated with standard wound therapy for a mean of 36.6 ± 31.58 weeks and with a mean baseline area of 10.15 ± 19.54 cm2 were followed up during a 12-week observation period or until they healed. A total of 18 of the wounds (90%) healed during the 12-week observation period, and none of the wounds progressed to amputation. From our experience with the patients in the present case series, we believe that granulized amniotic membrane and amniotic fluid represents a useful option for the treatment of chronic diabetic foot wounds.
机译：我们回顾了背景资料和以前的临床研究，这些研究考虑了使用同种异体羊膜组织和体液（粒化的羊膜和羊水）治疗慢性糖尿病足伤口。这项创新通过在非免疫原性组织组织基质中提供独特的活人同种异体移植物，代表了一种相对较新的伤口处理方法。颗粒状羊膜和羊水被开发用来填充软组织缺损和骨空隙并传达抗微生物和抗炎能力，不需要胎儿死亡，因为其采购是在出生时征得母亲同意的。在本研究中，在12周的观察期内随访了20例慢性伤口（20例患者），这些患者均接受了标准伤口治疗，平均36.6±31.58周，平均基线面积为10.15±19.54 cm2。直到他们he愈。在12周的观察期内，共有18处伤口愈合（90％），并且没有伤口进展为截肢。根据本病例系列患者的经验，我们认为颗粒化的羊膜和羊水代表了治疗慢性糖尿病足伤口的有用选择。

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